Many complex cellular events depend on multiprotein complexes known as molecular
machines to efficiently couple the energy derived from adenosine triphosphate hydrolysis to …

Argonaute (Ago) proteins are encoded in all three domains of life and are responsible for the
regulation of intracellular nucleic acid levels. Whereas some Ago variants are able to cleave …

DoriC, a database of replication origins, was initially created to present the bacterial oriC s
predicted by Ori-Finder or determined by experiments in 2007. DoriC 5.0, an updated …

In nature, microorganisms exhibit different volumes spanning six orders of magnitude.
Despite their capability to create different sizes, a clonal population in a given environment …

The DNA polymerase (Pol) δ of Saccharomyces cerevisiae (Sc) is composed of the catalytic
subunit Pol3 along with two regulatory subunits, Pol31 and Pol32. Pol δ binds to …

Archaea represents the third domain of life, displaying a closer relationship with eukaryotes
than bacteria. These microorganisms are valuable model systems for molecular biology and …

The machines that decode and regulate genetic information require the translation,
transcription and replication pathways essential to all living cells. Thus, it might be expected …

One of the key differences between Bacteria and Archaea is their canonical membrane
phospholipids, which are synthesized by distinct biosynthetic pathways with …

DNA replication origins strikingly differ between eukaryotic species and cell types. Origins
are localized and can be highly efficient in budding yeast, are randomly located in early fly …

Since first identified as a separate domain of life in the 1970s, it has become clear that
archaea differ profoundly from both eukaryotes and bacteria. In this review, we look across …