A biosocial return to race? A cautionary view for the postgenomic era
Recent studies demonstrating epigenetic and developmental sensitivity to early
environments, as exemplified by fields like the Developmental Origins of Health and …
environments, as exemplified by fields like the Developmental Origins of Health and …
Epigenetics applied to psychiatry: clinical opportunities and future challenges
L Kular, S Kular - Psychiatry and clinical neurosciences, 2018 - Wiley Online Library
Psychiatric disorders are clinically heterogeneous and debilitating chronic diseases
resulting from a complex interplay between gene variants and environmental factors …
resulting from a complex interplay between gene variants and environmental factors …
Genetic variation influencing DNA methylation provides insights into molecular mechanisms regulating genomic function
We determined the relationships between DNA sequence variation and DNA methylation
using blood samples from 3,799 Europeans and 3,195 South Asians. We identify …
using blood samples from 3,799 Europeans and 3,195 South Asians. We identify …
Novel diagnostic DNA methylation episignatures expand and refine the epigenetic landscapes of Mendelian disorders
MA Levy, H McConkey, J Kerkhof… - Human Genetics and …, 2022 - cell.com
Overlapping clinical phenotypes and an expanding breadth and complexity of genomic
associations are a growing challenge in the diagnosis and clinical management of …
associations are a growing challenge in the diagnosis and clinical management of …
DNMT inhibitors increase methylation in the cancer genome
AK Giri, T Aittokallio - Frontiers in pharmacology, 2019 - frontiersin.org
DNA methyltransferase inhibitors (DNMTi) decitabine and azacytidine are approved
therapies for myelodysplastic syndrome and acute myeloid leukemia, and their …
therapies for myelodysplastic syndrome and acute myeloid leukemia, and their …
Characterisation of ethnic differences in DNA methylation between UK-resident South Asians and Europeans
HR Elliott, K Burrows, JL Min, T Tillin, D Mason… - Clinical …, 2022 - Springer
Ethnic differences in non-communicable disease risk have been described between
individuals of South Asian and European ethnicity that are only partially explained by …
individuals of South Asian and European ethnicity that are only partially explained by …
Evidence for differences in DNA methylation between Germans and Japanese
J Becker, P Böhme, A Reckert, SB Eickhoff… - International Journal of …, 2022 - Springer
As a contribution to the discussion about the possible effects of ethnicity/ancestry on age
estimation based on DNA methylation (DNAm) patterns, we directly compared age …
estimation based on DNA methylation (DNAm) patterns, we directly compared age …
Genome-wide association study of blood lipids in Indians confirms universality of established variants
Lipids foster energy production and their altered levels have been coupled with metabolic
ailments. Indians feature high prevalence of metabolic diseases, yet uncharacterized for …
ailments. Indians feature high prevalence of metabolic diseases, yet uncharacterized for …
Epigenome-wide methylation study identified two novel CpGs associated with T2DM risk and a network of co-methylated CpGs capable of patient's classifications
Prevention of Type 2 diabetes mellitus (T2DM) pandemic needs markers that can precisely
predict the disease risk in an individual. Alterations in DNA methylations due to exposure …
predict the disease risk in an individual. Alterations in DNA methylations due to exposure …
Methylation profiles at birth linked to early childhood obesity
Childhood obesity represents a significant global health concern and identifying its risk
factors is crucial for developing intervention programs. Many “omics” factors associated with …
factors is crucial for developing intervention programs. Many “omics” factors associated with …