Metabolic reprogramming and epigenetic modifications on the path to cancer

L Sun, H Zhang, P Gao - Protein & cell, 2022 - academic.oup.com
Metabolic rewiring and epigenetic remodeling, which are closely linked and reciprocally
regulate each other, are among the well-known cancer hallmarks. Recent evidence …

[HTML][HTML] Pathophysiological mechanisms and therapeutic approaches in obstructive sleep apnea syndrome

R Lv, X Liu, Y Zhang, N Dong, X Wang, Y He… - Signal transduction and …, 2023 - nature.com
Obstructive sleep apnea syndrome (OSAS) is a common breathing disorder in sleep in
which the airways narrow or collapse during sleep, causing obstructive sleep apnea. The …

Obstructive sleep apnea, hypoxia, and nonalcoholic fatty liver disease

OA Mesarwi, R Loomba, A Malhotra - American journal of …, 2019 - atsjournals.org
Recent studies have demonstrated that obstructive sleep apnea (OSA) is associated with the
development and evolution of nonalcoholic fatty liver disease (NAFLD), independent of …

[HTML][HTML] Endothelial dysfunction driven by hypoxia—the influence of oxygen deficiency on NO bioavailability

A Janaszak-Jasiecka, A Siekierzycka, A Płoska… - Biomolecules, 2021 - mdpi.com
Cardiovascular diseases (CVDs) are the leading cause of death worldwide. The initial stage
of CVDs is characterized by endothelial dysfunction, defined as the limited bioavailability of …

Brain‐derived neurotrophic factor and post‐stroke depression

E Zhang, P Liao - Journal of neuroscience research, 2020 - Wiley Online Library
Brain‐derived neurotrophic factor (BDNF) is well known to play a critical role in cognition. Its
role in mood disorders, including post stroke depression (PSD), is also recognized with …

The potential of hyperbaric oxygen as a therapy for neurodegenerative diseases

P Mensah-Kane, N Sumien - GeroScience, 2023 - Springer
Abstract The World Health Organization estimates that by the year 2040, neurodegenerative
diseases will be the second leading cause of death in developed countries, overtaking …

Carotid body hypersensitivity in intermittent hypoxia and obtructive sleep apnoea

NR Prabhakar, YJ Peng, J Nanduri - The Journal of Physiology, 2023 - Wiley Online Library
Carotid bodies are the principal sensory organs for detecting changes in arterial blood
oxygen concentration, and the carotid body chemoreflex is a major regulator of the …

[HTML][HTML] Hypoxia: molecular pathophysiological mechanisms in human diseases

Y Della Rocca, L Fonticoli, TS Rajan, O Trubiani… - Journal of physiology …, 2022 - Springer
Hypoxia, a low O2 tension, is a fundamental feature that occurs in physiological events as
well as pathophysiological conditions, especially mentioned for its role in the mechanism of …

Rostral ventrolateral medulla and hypertension

PG Guyenet, RL Stornetta, BB Holloway… - …, 2018 - Am Heart Assoc
560 Hypertension September 2018 of interest in the potential contribution of sympatho-
respiratory coupling to SNA elevation in neurogenic hypertension. As summarized below …

Maternal obesity increases DNA methylation and decreases RNA methylation in the human placenta

WB Shen, J Ni, R Yao, KR Goetzinger, C Harman… - Reproductive …, 2022 - Elsevier
Maternal obesity is associated with increased risk of adverse pregnancy and birth outcomes.
While increasing body of evidence supports that the etiology is related to fetal and placental …