Methyl donor micronutrients that modify DNA methylation and cancer outcome
AM Mahmoud, MM Ali - Nutrients, 2019 - mdpi.com
DNA methylation is an epigenetic mechanism that is essential for regulating gene
transcription. However, aberrant DNA methylation, which is a nearly universal finding in …
transcription. However, aberrant DNA methylation, which is a nearly universal finding in …
[HTML][HTML] Understanding the interplay between CpG island-associated gene promoters and H3K4 methylation
The precise regulation of gene transcription is required to establish and maintain cell type-
specific gene expression programs during multicellular development. In addition to …
specific gene expression programs during multicellular development. In addition to …
DNA methylation profiling to predict recurrence risk in meningioma: development and validation of a nomogram to optimize clinical management
Background Variability in standard-of-care classifications precludes accurate predictions of
early tumor recurrence for individual patients with meningioma, limiting the appropriate …
early tumor recurrence for individual patients with meningioma, limiting the appropriate …
Senescent cells harbour features of the cancer epigenome
Altered DNA methylation and associated destabilization of genome integrity and function is
a hallmark of cancer. Replicative senescence is a tumour suppressor process that imposes …
a hallmark of cancer. Replicative senescence is a tumour suppressor process that imposes …
Epigenetic aging: more than just a clock when it comes to cancer
M Yu, WD Hazelton, GE Luebeck, WM Grady - Cancer research, 2020 - AACR
The incidence of cancer, adjusted for secular trends, is directly related to age, and advanced
chronologic age is one of the most significant risk factors for cancer. Organismal aging is …
chronologic age is one of the most significant risk factors for cancer. Organismal aging is …
Epigenetic alterations and inflammation as emerging use for the advancement of treatment in non-small cell lung cancer
Lung cancer remains one of the most common malignancies in the world. Nowadays, the
most common lung cancer is non-small cell lung cancer (NSCLC), namely …
most common lung cancer is non-small cell lung cancer (NSCLC), namely …
Rapid reprogramming of epigenetic and transcriptional profiles in mammalian culture systems
CE Nestor, R Ottaviano, D Reinhardt, HA Cruickshanks… - Genome biology, 2015 - Springer
Background The DNA methylation profiles of mammalian cell lines differ from those of the
primary tissues from which they were derived, exhibiting increasing divergence from the in …
primary tissues from which they were derived, exhibiting increasing divergence from the in …
Changes in correlation between promoter methylation and gene expression in cancer
Background Methylation of high-density CpG regions known as CpG Islands (CGIs) has
been widely described as a mechanism associated with gene expression regulation …
been widely described as a mechanism associated with gene expression regulation …
Genome-wide analyses reveal a role of Polycomb in promoting hypomethylation of DNA methylation valleys
Background Previous studies showed that the majority of developmental genes are devoid
of DNA methylation at promoters even when they are repressed. Such hypomethylated …
of DNA methylation at promoters even when they are repressed. Such hypomethylated …
Non‐canonical bases in the genome: the regulatory information layer in DNA
T Carell, MQ Kurz, M Müller, M Rossa… - Angewandte Chemie …, 2018 - Wiley Online Library
Multicellular organisms developed the concept of specialized cells that perform specific
functions. Examples are neurons and fibroblast to name just two out of more than 200 …
functions. Examples are neurons and fibroblast to name just two out of more than 200 …