Background Sex differences are known to play a role in disease aetiology, progression and
outcome. Previous studies have revealed autosomal epigenetic differences between males …

DNA methylation (DNAm)-based age clocks have been studied extensively as a biomarker
of human ageing and a risk factor for age-related diseases. Despite different tissues having …

Motivation Data normalization is an essential step to reduce technical variation within and
between arrays. Due to the different karyotypes and the effects of X chromosome …

Background Genome-wide DNA methylation (DNAme) profiling of the placenta with Illumina
Infinium Methylation bead arrays is often used to explore the connections between in utero …

Klinefelter syndrome (KS) is the most prevalent chromosomal disorder occurring in males. It
is defined by an additional X chromosome, 47, XXY, resulting from errors in chromosomal …

Geographically isolated populations, specifically island‐mainland counterparts, tend to
exhibit phenotypic variation in many species. The so‐called island syndrome occurs when …

Epigenetic sex differences and their resulting implications for human health have been
studied for about a decade. The objective of this paper is to use permutation-based …

Identifying and validating biomarkers of aging is pivotal for understanding the aging process
and testing longevity interventions. Despite the development of numerous aging biomarkers …

Population-scale expression profiling studies can provide valuable insights into biological
and disease-underlying mechanisms. The availability of phenotypic traits is essential for …

Unlike genomes, which are static throughout the lifespan of an organism, DNA methylomes
are dynamic. To study these dynamics, we developed quantitative models that measure the …