We now know that cancer is many different diseases, with great variation even within a
single histological subtype. With the current emphasis on developing personalized …

Despite their known importance in clinical medicine, differences based on sex and gender
are among the least studied factors affecting cancer susceptibility, progression, survival, and …

Epigenetic processes play a key role in orchestrating transcriptional regulation during
development. The importance of DNA methylation in fetal brain development is highlighted …

Abstract Background Type 2 diabetes (T2D) is a multifactorial, polygenic disease caused by
impaired insulin secretion and insulin resistance. Genome-wide association studies (GWAS) …

Background DNA methylation is an important epigenetic mark that can potentially link early
life exposures to adverse health outcomes later in life. Host factors like sex and age strongly …

Background Disease risk and incidence between males and females reveal differences, and
sex is an important component of any investigation of the determinants of phenotypes or …

Background Sex differences are known to play a role in disease aetiology, progression and
outcome. Previous studies have revealed autosomal epigenetic differences between males …

More than two‐thirds of patients suffering from stress‐related disorders are women but over
two‐thirds of suicide completers are men. These are just some examples of the many sex …

High deviations resulting from prediction model, gender and population difference have
limited age estimation application of DNA methylation markers. Here we identified 2,957 …

Alzheimer's disease (AD) is characterized by specific alterations of brain DNA methylation
(DNAm) patterns. Age and sex, two major risk factors for AD, are also known to largely affect …