Comprehensive review on Alzheimer's disease: causes and treatment
Z Breijyeh, R Karaman - Molecules, 2020 - mdpi.com
Alzheimer's disease (AD) is a disorder that causes degeneration of the cells in the brain and
it is the main cause of dementia, which is characterized by a decline in thinking and …
it is the main cause of dementia, which is characterized by a decline in thinking and …
Epigenetics of Alzheimer's disease
There are currently no validated biomarkers which can be used to accurately diagnose
Alzheimer's disease (AD) or to distinguish it from other dementia-causing neuropathologies …
Alzheimer's disease (AD) or to distinguish it from other dementia-causing neuropathologies …
[HTML][HTML] Inhibition of miR-331-3p and miR-9-5p ameliorates Alzheimer's disease by enhancing autophagy
ML Chen, CG Hong, T Yue, HM Li, R Duan, WB Hu… - Theranostics, 2021 - ncbi.nlm.nih.gov
Alzheimer's disease (AD) is currently ranked as the third leading cause of death for eldly
people, just behind heart disease and cancer. Autophagy is declined with aging. Our study …
people, just behind heart disease and cancer. Autophagy is declined with aging. Our study …
[HTML][HTML] Mechanisms of short-chain fatty acids derived from gut microbiota in Alzheimer's disease
X Qian, R Xie, X Liu, H Tang - Aging and disease, 2022 - ncbi.nlm.nih.gov
Short-chain fatty acids (SCFAs) are important metabolites derived from the gut microbiota
through fermentation of dietary fiber. SCFAs participate a number of physiological and …
through fermentation of dietary fiber. SCFAs participate a number of physiological and …
Histone modifications in Alzheimer's disease
DA Santana, MAC Smith, ES Chen - Genes, 2023 - mdpi.com
Since Late-onset Alzheimer's disease (LOAD) derives from a combination of genetic variants
and environmental factors, epigenetic modifications have been predicted to play a role in the …
and environmental factors, epigenetic modifications have been predicted to play a role in the …
Epigenome-wide meta-analysis of DNA methylation differences in prefrontal cortex implicates the immune processes in Alzheimer's disease
DNA methylation differences in Alzheimer's disease (AD) have been reported. Here, we
conducted a meta-analysis of more than 1000 prefrontal cortex brain samples to prioritize …
conducted a meta-analysis of more than 1000 prefrontal cortex brain samples to prioritize …
Targeting epigenetics: A novel promise for Alzheimer's disease treatment
D Jeremic, L Jiménez-Díaz, JD Navarro-López - Ageing Research Reviews, 2023 - Elsevier
So far, the search for a cure for Alzheimer Disease (AD) has been unsuccessful. The only
approved drugs attenuate some symptoms, but do not halt the progress of this disease …
approved drugs attenuate some symptoms, but do not halt the progress of this disease …
Insulinopathies of the brain? Genetic overlap between somatic insulin-related and neuropsychiatric disorders
The prevalence of somatic insulinopathies, like metabolic syndrome (MetS), obesity, and
type 2 diabetes mellitus (T2DM), is higher in Alzheimer's disease (AD), autism spectrum …
type 2 diabetes mellitus (T2DM), is higher in Alzheimer's disease (AD), autism spectrum …
The role of epigenetics in neuroinflammatory-driven diseases
S Giallongo, L Longhitano, S Denaro… - International Journal of …, 2022 - mdpi.com
Neurodegenerative disorders are characterized by the progressive loss of central and/or
peripheral nervous system neurons. Within this context, neuroinflammation comes up as one …
peripheral nervous system neurons. Within this context, neuroinflammation comes up as one …
Inhibition of histone methyltransferase Smyd3 rescues NMDAR and cognitive deficits in a tauopathy mouse model
Pleiotropic mechanisms have been implicated in Alzheimer's disease (AD), including
transcriptional dysregulation, protein misprocessing and synaptic dysfunction, but how they …
transcriptional dysregulation, protein misprocessing and synaptic dysfunction, but how they …