During the past few decades, it has become increasingly apparent that heredity is not the
sole determining factor in disease development, such as cancer. This landmark work covers …

Abnormal development and fetal loss during postimplantation period are concerns for
production of nuclear transferred animals. Aberrant DNA methylation is one of the reasons …

DNA methylation profile, consisting of tissue‐dependent and differentially methylated
regions (T‐DMRs), has elucidated tissue‐specific gene function in mouse tissues. Here, we …

Disorders such as chronic fatigue syndrome (CFS) and gulf war syndrome (GWS) are
characterised by prolonged fatigue and a range of debilitating symptoms of pain, intellectual …

CpG islands, which have higher GC content and CpG frequencies compared to the genome
as a whole, are generally believed to be unmethylated in tissues except at promoters of …

Background Epigenetic regulation of oocyte-specific maternal factors is essential for oocyte
and early embryonic development. KPNA7 is an oocyte-specific maternal factor, which …

Background Tissues and their component cells have unique DNA methylation profiles
comprising DNA methylation patterns of tissue-dependent and differentially methylated …

Orexin neurons regulate critical brain activities for controlling sleep, eating, emotions, and
metabolism, and impaired orexin neuron function results in several neurologic disorders …

Ever since the derivation of the first human embryonic stem cell line, hopes have persisted
for the treatment of a wide range of cellular degenerative diseases. However, significant …

Abstract Fibrillin-1 (FBN1) is responsible for haploinsufficient and autosomal dominant
Marfan syndrome. Even in the same Marfan pedigree, penetrance and expressivity in …