T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive type of blood cancer that
accounts for about 15% of pediatric and 25% of adult acute lymphoblastic leukemia (ALL) …

T follicular helper (Tfh) cells express transcription factor BCL-6 and cytokine IL-21. Mature
Tfh cells are also capable of producing IFN-γ without expressing the Th1 transcription factor …

T cell lymphopoiesis is a complex, stepwise process in which the transcriptional program of
the progenitor cells is progressively adapted in order to generate mature phenotypes. This …

Abstract Lunatic, Manic, and Radical Fringe (LFNG, MFNG, and RFNG) are N-
acetylglucosaminyltransferases that modify Notch receptors and regulate Notch signaling …

The production of mature eosinophils (Eos) is a tightly orchestrated process with the aim to
sustain normal Eos levels in tissues while also maintaining low numbers of these complex …

Gene regulatory network modeling has played a major role in advancing the understanding
of developmental systems, by crystallizing structures of relevant extant information, by …

Cascades of transcriptional regulation are the common source of the forward drive in all
developmental systems. Increases in complexity and specificity of gene expression at …

Gene regulatory networks account for the ability of the genome to program development in
complex multi-cellular organisms. Such networks are based on principles of gene regulation …

该文旨在研究Arrb1 (β-arrestin1) 基因敲除对小鼠T 细胞发育的影响, 进一步探讨急性T
淋巴细胞白血病(T-cell acute lymphocytic leukemia, T-ALL) 发病机制. 该文使用q-PCR …

Thymic involution is evolutionarily conserved and occurs early in life. However, the
physiological significance remains elusive of this seemingly detrimental process. The …