[HTML][HTML] Phthalates' exposure leads to an increasing concern on cardiovascular health

M Mariana, M Castelo-Branco, AM Soares… - Journal of Hazardous …, 2023 - Elsevier
Being an essential component in the plastics industry, phthalates are ubiquitous in the
environment and in everyday life. They are considered environmental contaminants that …

Adverse cardiovascular effects and potential molecular mechanisms of DEHP and its metabolites—a review

ZJ Wen, ZY Wang, YF Zhang - Science of The Total Environment, 2022 - Elsevier
Currently, cardiovascular disease (CVD) is a health hazard that is associated with
progressive deterioration upon exposure to environmental pollutants. Di (2-ethylhexyl) …

[HTML][HTML] Killing two birds with one stone: Pregnancy is a sensitive window for endocrine effects on both the mother and the fetus

I Plante, LM Winn, C Vaillancourt, P Grigorova… - Environmental …, 2022 - Elsevier
Pregnancy is a complex process requiring tremendous physiological changes in the mother
in order to fulfill the needs of the growing fetus, and to give birth, expel the placenta and …

Impact of environmental phthalate on human health and their bioremediation strategies using fungal cell factory-A review

KV Naveen, K Saravanakumar, X Zhang… - Environmental …, 2022 - Elsevier
Phthalates are utilized as plasticizers in plastic products to enhance their durability,
transparency, and elasticity. However, phthalates are not covalently bonded to the polymer …

[HTML][HTML] Protective role of curcumin on broiler liver by modulating aflatoxin B1-induced DNA methylation and CYPs expression

R Liu, Y Ding, W Li, S Li, X Li, D Zhao, Y Zhang… - Ecotoxicology and …, 2023 - Elsevier
The purpose of this study was to investigate the role of epigenetic DNA methylation and
CYPs expression in AFB1-exposed broiler liver and the protective effect of curcumin. Sixty …

Effect of prenatal exposure to phthalates on epigenome-wide DNA methylations in cord blood and implications for fetal growth: The Hokkaido Study on Environment …

R Miura, A Ikeda-Araki, T Ishihara, K Miyake… - Science of the total …, 2021 - Elsevier
Prenatal exposure to phthalates negatively affects the offspring's health. In particular,
epigenetic alterations, such as DNA methylation, may connect phthalate exposure with …

Sexual dimorphism of the heart: genetics, epigenetics, and development

DF Deegan, P Nigam, N Engel - Frontiers in cardiovascular medicine, 2021 - frontiersin.org
The democratization of genomic technologies has revealed profound sex biases in
expression patterns in every adult tissue, even in organs with no conspicuous differences …

Developmental exposures to common environmental contaminants, DEHP and lead, alter adult brain and blood hydroxymethylation in mice

RL Petroff, RG Cavalcante, JA Colacino… - Frontiers in Cell and …, 2023 - frontiersin.org
The developing epigenome changes rapidly, potentially making it more sensitive to toxicant
exposures. DNA modifications, including methylation and hydroxymethylation, are important …

JAK3/STAT5b/PPARγ pathway mediates the association between di (2-ethylhexyl) phthalate exposure and lipid metabolic disorder in Chinese adolescent students

Q Xu, S Ding, W Qi, X Zhang, M Zhang… - Chemical Research …, 2023 - ACS Publications
Our previous studies found that di (2-ethylhexyl) phthalate (DEHP) could disorder lipid
metabolism in adolescents but the mechanisms underlying this association remained …

Sex-specific alterations in cardiac DNA methylation in adult mice by perinatal lead exposure

LK Svoboda, K Wang, TR Jones, JA Colacino… - International Journal of …, 2021 - mdpi.com
Environmental factors play an important role in the etiology of cardiovascular diseases.
Cardiovascular diseases exhibit marked sexual dimorphism; however, the sex-specific …