The acute or chronic drug treatments for different neurodegenerative and psychiatric
disorders are challenging from several aspects. The low bioavailability and limited brain …

Midazolam is a commonly used benzodiazepine in palliative care and is considered one of
the four essential drugs needed for the promotion of quality care in dying patients. Acting on …

Objective Seizures are a common neonatal neurologic emergency. Many centers have
developed pathways to optimize management. We evaluated neonatal seizure management …

Morphine is an agonist of the µ and k receptors, whose activation results in analgesia.
Morphine-like agonists act through the µ opioid receptors to cause pain relief, sedation …

Most seizure emergencies occur outside of the hospital, and there is a need for treatment
interventions that can be administered quickly and safely by nonclinical caregivers …

Seizures are common in neonates with moderate and severe hypoxic ischemic
encephalopathy (HIE) and are associated with worse outcomes, independent of HIE …

Context: Laryngoscopy is frequently required in neonatal intensive care. Awake
laryngoscopy has deleterious effects but practice remains heterogeneous regarding …

The intensive use of anesthetic and sedative agents in the neonatal intensive care unit
(NICU) has raised controversial concerns about the potential neurodevelopmental risks …

Almost 50% of prescription drugs lack age-appropriate dosing guidelines and therefore are
used “off-label.” Only~ 10% drugs prescribed to neonates and infants have been studied for …

The administration of drugs to neonates poses significant challenges. The aim of this review
was to provide insight into some of these challenges and resolutions that may be …