The developing brain, particularly in premature infants, is highly susceptible to
environmental and pharmacological influences. Premature neonates often require …

Purpose The aim of the present study was to develop a population pharmacokinetic model
of midazolam, and to evaluate the influence of maturation process and other variability …

Background: Existing therapeutic alternatives for neonatal crises have expanded in recent
decades, but no consensus has been reached on protocols based on neonatal seizures. In …

Midazolam is a drug belonging to the benzodiazepine group and is used commonly for
seizure control as well as preoperative and procedure-related sedation in neonates. Many …

OBJECTIVES: The objectives of this study are to describe (1) the clinical pharmacology of
analgesics in infants and (2) the pharmacologic management of pain in neonates …

First dose prediction is challenging in neonates. Our objective in this proof-of-concept study
was to perform a pharmacokinetic (PK) bridging study from juvenile mice to neonates for …

Children with cancer often require sedation before undergoing invasive procedures.
Fentanyl, ketamine, and midazolam are effective drugs widely used for procedural sedation …

Background Temozolomide (TMZ) induces a G2/M cell cycle arrest and is used for treatment
of paediatric tumours, especially neuroblastomas. Patients treated with TMZ frequently …

Abstract GABA A receptors (GABA AR) are inhibitory ion channels ubiquitously expressed in
the central nervous system and play critical roles in brain development and function …

Induction of anesthesia, each patient can get a variety of premedications. The selection of
anesthetic drugs should be based on patient characteristics and conditions associated with …