The Poly (ADP-ribose) polymerase (PARP) family has many essential functions in cellular
processes, including the regulation of transcription, apoptosis and the DNA damage …

Growing evidence suggests that aberrant epigenetic regulation of gene function is strongly
related to the genesis of cancer. Unlike genetic mutations, the ability to reprogram the …

In mammals, DNA methylation occurs mainly at CpG dinucleotides. Methylation of the
promoter suppresses gene expression, but the functional role of gene-body DNA …

The early detection of cancer can significantly reduce cancer mortality and saves lives. Thus,
a great deal of effort has been devoted to the exploration of new technologies to detect early …

The past 15 years have seen an explosion of discoveries related to the cellular regulation of
phenotypes through epigenetic mechanisms. This regulation provides a software that …

DNA methylation was first described almost a century ago; however, the rules governing its
establishment and maintenance remain elusive. Here we present data demonstrating that …

Cancer is the second leading cause of death in US. Despite the emergence of new, targeted
agents, and the use of various therapeutic combinations, none of the available treatment …

Allergic diseases are on the rise in the Western world and well-known allergy-protecting and-
driving factors such as microbial and dietary exposure, pollution and smoking mediate their …

Epigenetics has long been recognized as a significant field in biology and is defined as the
investigation of any alteration in gene expression patterns that is not attributed to changes in …

Azacytidine was first synthesized almost 40 years ago. It was demonstrated to have a wide
range of anti-metabolic activities when tested against cultured cancer cells and to be an …