Chemical reprogramming offers an unprecedented opportunity to control somatic cell fate
and generate desired cell types including pluripotent stem cells for applications in …

Nuclear deformation, a hallmark frequently observed in senescent cells, is presumed to be
associated with the erosion of chromatin organization at the nuclear periphery. However …

Accumulating evidence indicates an association between the circadian clock and the aging
process. However, it remains elusive whether the deregulation of circadian clock proteins …

Pluripotent stem cells, having long been considered the fountain of youth, have caught the
attention of many researchers from diverse backgrounds due to their capacity for unlimited …

Chemical reprogramming provides a powerful platform for exploring the molecular dynamics
that lead to pluripotency. Although previous studies have uncovered an intermediate …

Recent studies have revealed that a combination of chemical compounds enables direct
reprogramming from one somatic cell type into another without the use of transgenes by …

Cellular fate reprogramming holds great promise to generate functional cell types for
replenishing new cells and restoring functional loss. Inspired by transcription factor-induced …

Introduction Pluripotent stem cells can be generated from somatic cells by the Yamanaka
factors Oct4, Sox2, Klf4 and c-Myc. Methods Mouse embryonic fibroblasts (MEFs) were …

The nucleosome is the fundamental subunit of chromatin. Nucleosome structures are formed
by the combination of histone octamers and genomic DNA. Through a systematic and …

The nature of somatic cell fate has always been considered relatively unchangeable. Only in
rare cases, in response to highly specific environmental cues, do differentiated mammalian …