Redox homeostasis refers to the balance between the production of reactive oxygen species
(ROS) as well as reactive nitrogen species (RNS), and their elimination by antioxidants. It is …

Hydrazine-related chemicals (HRCs) with carcinogenic and neurotoxic potential are found in
certain mushrooms and plants used for food and in products employed in various industries …

DNA damage is implicated in the pathogenesis of amyotrophic lateral sclerosis (ALS).
However, relationships between DNA damage accumulation, DNA damage response …

Alzheimer's disease (AD) is a progressive neurodegenerative disease that accounts for a
majority of dementia cases. AD is characterized by progressive neuronal death associated …

Perinatal hypoxia-ischemia resulting in death or lifelong disabilities remains a major clinical
disorder. Neonatal models of hypoxia-ischemia in rodents have enhanced our …

Stable and predictive neural cell culture models are a necessary premise for many research
fields. However, conventional 2D models lack 3D cell‐material/‐cell interactions and hence …

The effects of hypothermia on neonatal encephalopathy may vary topographically and
cytopathologically in the neocortex with manifestations potentially influenced by seizures …

In brain, the striatum is a heterogenous region involved in reward and goal-directed
behaviors. Striatal dysfunction is linked to psychiatric disorders, including opioid use …

Mechanism-based risk assessment is urged to advance and fully permeate into current
safety assessment practices, possibly at early phases of drug safety testing. Toxicogenomics …

The underlying molecular mechanisms associated with sporadic Alzheimer's disease (AD),
a progressive neurodegenerative disease, are not yet fully understood. Adult neurons are …