US general Ulysses S. Grant once said:“The art of war is simple enough. Find out where
your enemy is. Get at him as soon as you can. Strike him as hard as you can.” The decision …

A DNA polymerase is essential for DNA replication. Although this may now seem obvious,
the first indication that this is indeed the case did not come until nearly a decade after the …

Inhibition constants were determined for 16 nucleoside analog triphosphates against human
DNA polymerases alpha, beta, gamma, and epsilon, and 7 nucleoside analogs were …

In Saccharomyces cerevisiae, DNA polymerase delta (POLIII), the product of the CDC2
(POL3) gene, possesses, in its N‐terminal half, the well conserved 3‐domain 3′ to 5 …

In addition to the general 3′–5′ exonuclease domain described by Bernad et al.[Cell 59
(1989) 219–228] significant amino acid (aa) sequence similarity has been found in the C …

In the search for 1-[(2-hydroxyethoxy)-methyl]-6-(phenylthio) thymine (HEPT) derivatives, we
have found several 5-ethyl-6-(phenylthio) uracil analogues to be highly potent and selective …

The Bacillus subtilis phage luminal diameter 29 DNA polymerase, involved in protein‐
primed viral DNA replication, was inhibited by phosphonoacetic acid (PAA), a known …

Three nuclear DNA polymerases have been described in yeast: DNA polymerases I, II, and
Ill. DNA polymerase I is encoded by the POLI gene and is essential for DNA replication …

Five site-directed mutations were introduced at the most conserved amino acids in region I
(YGDTDS) of the human DNA polymerase alpha catalytic subunit. Mutant proteins were …

Correspondence: ILA. Bambara, Department of Biochemistry, Box 607, University of
Rochester Medical Center. 601 Elmwood Avenue, Rochester, NY 14642, USA and recent …