The kidney plays a major role in the elimination of drugs. The purpose of this paper is to:(i)
review the mechanisms of renal elimination;(ii) identify potential mechanisms for renal drug …

The importance of immunologic processes in the pathogenesis of glomerulonephritis has
long been recognized, and over the past 30 years considerable progress has been made …

A chronic renal disease was induced by 5/6 nephrectomy in young adult Wistar albino male
rats. Groups of 3 rats were killed at varying time intervals from 10 to 50 weeks after …

Dialytic clearance of urea is efficient, but other small solutes normally secreted by the kidney
may be cleared less efficiently. This study tested whether the high concentrations of these …

The kidney clears numerous solutes from the plasma; however, retention of these solutes
causes uremic illness when the kidneys fail. We know remarkably little about which retained …

A century has passed since we have been able to remove diseased renal tissue.
Conservative management of renal disease has been advocated by such early innovators …

Advances in the conservative management of patients with chronic renal insufficiency have
reaffirmed the need for the accurate measurement of glomerular filtration rate (GFR). The …

This book contains over 100 chapters. Some of the chapter titles are: Intravenous
Urography, Ultrasonography, and Radionuclide Studies; Computed Tomography and …

METHODS Male rats of the Wistar strain weighing from 200 to 410 gm. were given
subcutaneous injections of either 0.7 to 1.5 mg. of potassium dichromate or 0.5 to 1.0 rag. of …

Background The clearance of solutes removed by tubular secretion may be altered out of
proportion to the GFR in CKD. Recent studies have described considerable variability in the …