Aging is a complex, multifaceted process that induces a myriad of physiological changes
over an extended period of time. Aging is accompanied by major biochemical and …

Systems biology provides a framework for assembling models of biological systems from
systematic measurements. Since the field was first introduced a decade ago, considerable …

To elucidate cellular events underlying the pluripotency of human embryonic stem cells
(hESCs), we performed parallel quantitative proteomic and phosphoproteomic analyses of …

DNA methylation is a dynamic epigenetic mark that undergoes extensive changes during
differentiation of self-renewing stem cells. However, whether these changes are the cause or …

During early mammalian development, as the pluripotent cells that give rise to all of the
tissues of the body proliferate and expand in number, they pass through transition states …

Reversing or slowing the aging process brings great promise to treat or prevent age‐related
disease, and targeting the hallmarks of aging is a strategy to achieve this. Epigenetics …

How long organisms live is not entirely written in their genes. Recent findings reveal that
epigenetic factors that regulate histone methylation, a type of chromatin modification, can …

The nucleus is the distinguishing feature of eukaryotic cells. Until recently, it was often
considered simply as a unique compartment containing the genetic information of the cell …

Canonical Wnt signaling supports the formation and maintenance of stem and cancer stem
cells. Recent studies have elucidated epigenetic mechanisms that control pluripotency and …

DNA methylation is known to be associated with cell differentiation, aging, disease and
cancer. There exists an expanding base of knowledge regarding tissue-specific DNA …