The mechanobiology of aging
JM Phillip, I Aifuwa, J Walston… - Annual review of …, 2015 - annualreviews.org
Aging is a complex, multifaceted process that induces a myriad of physiological changes
over an extended period of time. Aging is accompanied by major biochemical and …
over an extended period of time. Aging is accompanied by major biochemical and …
A decade of systems biology
Systems biology provides a framework for assembling models of biological systems from
systematic measurements. Since the field was first introduced a decade ago, considerable …
systematic measurements. Since the field was first introduced a decade ago, considerable …
System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation
KTG Rigbolt, TA Prokhorova, V Akimov… - Science …, 2011 - science.org
To elucidate cellular events underlying the pluripotency of human embryonic stem cells
(hESCs), we performed parallel quantitative proteomic and phosphoproteomic analyses of …
(hESCs), we performed parallel quantitative proteomic and phosphoproteomic analyses of …
DNA methylation protects hematopoietic stem cell multipotency from myeloerythroid restriction
AM Bröske, L Vockentanz, S Kharazi, MR Huska… - Nature …, 2009 - nature.com
DNA methylation is a dynamic epigenetic mark that undergoes extensive changes during
differentiation of self-renewing stem cells. However, whether these changes are the cause or …
differentiation of self-renewing stem cells. However, whether these changes are the cause or …
Extrinsic regulation of pluripotent stem cells
MF Pera, PPL Tam - Nature, 2010 - nature.com
During early mammalian development, as the pluripotent cells that give rise to all of the
tissues of the body proliferate and expand in number, they pass through transition states …
tissues of the body proliferate and expand in number, they pass through transition states …
From molecular promise to preclinical results: HDAC inhibitors in the race for healthy aging drugs
RL McIntyre, EG Daniels, M Molenaars… - EMBO molecular …, 2019 - embopress.org
Reversing or slowing the aging process brings great promise to treat or prevent age‐related
disease, and targeting the hallmarks of aging is a strategy to achieve this. Epigenetics …
disease, and targeting the hallmarks of aging is a strategy to achieve this. Epigenetics …
Histone methylation makes its mark on longevity
How long organisms live is not entirely written in their genes. Recent findings reveal that
epigenetic factors that regulate histone methylation, a type of chromatin modification, can …
epigenetic factors that regulate histone methylation, a type of chromatin modification, can …
[HTML][HTML] Mechanics of the nucleus
J Lammerding - Comprehensive physiology, 2011 - ncbi.nlm.nih.gov
The nucleus is the distinguishing feature of eukaryotic cells. Until recently, it was often
considered simply as a unique compartment containing the genetic information of the cell …
considered simply as a unique compartment containing the genetic information of the cell …
Wnt signaling in stem and cancer stem cells
P Wend, JD Holland, U Ziebold… - Seminars in cell & …, 2010 - Elsevier
Canonical Wnt signaling supports the formation and maintenance of stem and cancer stem
cells. Recent studies have elucidated epigenetic mechanisms that control pluripotency and …
cells. Recent studies have elucidated epigenetic mechanisms that control pluripotency and …
Epigenetic profiling of somatic tissues from human autopsy specimens identifies tissue-and individual-specific DNA methylation patterns
HM Byun, KD Siegmund, F Pan… - Human molecular …, 2009 - academic.oup.com
DNA methylation is known to be associated with cell differentiation, aging, disease and
cancer. There exists an expanding base of knowledge regarding tissue-specific DNA …
cancer. There exists an expanding base of knowledge regarding tissue-specific DNA …