Human cancer cell lines are an integral part of drug discovery practices. However, modeling
the complexity of cancer utilizing these cell lines on standard plastic substrata, does not …

The ability of environmental factors to promote a phenotype or disease state not only in the
individual exposed but also in subsequent progeny for successive generations is termed …

The majority of environmental factors can not modify DNA sequence, but can influence the
epigenome. The mitotic stability of the epigenome and ability of environmental epigenetics …

Previous observations have demonstrated that embryonic exposure to the endocrine
disruptor vinclozolin during gonadal sex determination promotes transgenerational adult …

Despite advances in the prevention and management of cardiovascular disease (CVD), this
group of multifactorial disorders remains a leading cause of mortality worldwide. CVD is …

The prevalence, the prognostic effect, and interaction with other molecular markers of
DNMT3A mutations was studied in 415 patients with acute myeloid leukemia (AML) younger …

Chromosomal regions can adopt stable and heritable alternative states resulting in bistable
gene expression without changes to the DNA sequence. Such epigenetic control is often …

The endocrine disruptor vinclozolin has previously been shown to promote epigenetic
transgenerational inheritance of adult onset disease in the rat. The current study was …

Environmental factors have a significant impact on biology. Therefore, environmental
toxicants through similar mechanisms can modulate biological systems to influence …

The burden of adverse pregnancy outcomes such as preterm birth and low birth weight is
considerable across the world. Several risk factors for adverse pregnancy outcomes have …