Advanced cell culture techniques for cancer drug discovery
CJ Lovitt, TB Shelper, VM Avery - Biology, 2014 - mdpi.com
Human cancer cell lines are an integral part of drug discovery practices. However, modeling
the complexity of cancer utilizing these cell lines on standard plastic substrata, does not …
the complexity of cancer utilizing these cell lines on standard plastic substrata, does not …
Epigenetic transgenerational actions of environmental factors in disease etiology
MK Skinner, M Manikkam… - Trends in Endocrinology & …, 2010 - cell.com
The ability of environmental factors to promote a phenotype or disease state not only in the
individual exposed but also in subsequent progeny for successive generations is termed …
individual exposed but also in subsequent progeny for successive generations is termed …
[HTML][HTML] Environmental epigenetic transgenerational inheritance and somatic epigenetic mitotic stability
MK Skinner - Epigenetics, 2011 - ncbi.nlm.nih.gov
The majority of environmental factors can not modify DNA sequence, but can influence the
epigenome. The mitotic stability of the epigenome and ability of environmental epigenetics …
epigenome. The mitotic stability of the epigenome and ability of environmental epigenetics …
Epigenetic transgenerational actions of vinclozolin on promoter regions of the sperm epigenome
Previous observations have demonstrated that embryonic exposure to the endocrine
disruptor vinclozolin during gonadal sex determination promotes transgenerational adult …
disruptor vinclozolin during gonadal sex determination promotes transgenerational adult …
Epigenetics and cardiovascular disease
JM Ordovás, CE Smith - Nature Reviews Cardiology, 2010 - nature.com
Despite advances in the prevention and management of cardiovascular disease (CVD), this
group of multifactorial disorders remains a leading cause of mortality worldwide. CVD is …
group of multifactorial disorders remains a leading cause of mortality worldwide. CVD is …
Mutant DNMT3A: a marker of poor prognosis in acute myeloid leukemia
AFT Ribeiro, M Pratcorona… - Blood, The Journal …, 2012 - ashpublications.org
The prevalence, the prognostic effect, and interaction with other molecular markers of
DNMT3A mutations was studied in 415 patients with acute myeloid leukemia (AML) younger …
DNMT3A mutations was studied in 415 patients with acute myeloid leukemia (AML) younger …
[HTML][HTML] Theoretical analysis of epigenetic cell memory by nucleosome modification
Chromosomal regions can adopt stable and heritable alternative states resulting in bistable
gene expression without changes to the DNA sequence. Such epigenetic control is often …
gene expression without changes to the DNA sequence. Such epigenetic control is often …
Epigenetic transgenerational inheritance of vinclozolin induced mouse adult onset disease and associated sperm epigenome biomarkers
C Guerrero-Bosagna, TR Covert, MM Haque… - Reproductive …, 2012 - Elsevier
The endocrine disruptor vinclozolin has previously been shown to promote epigenetic
transgenerational inheritance of adult onset disease in the rat. The current study was …
transgenerational inheritance of adult onset disease in the rat. The current study was …
Epigenetic transgenerational actions of endocrine disruptors
MK Skinner, M Manikkam, C Guerrero-Bosagna - Reproductive toxicology, 2011 - Elsevier
Environmental factors have a significant impact on biology. Therefore, environmental
toxicants through similar mechanisms can modulate biological systems to influence …
toxicants through similar mechanisms can modulate biological systems to influence …
Praegnatio perturbatio—impact of endocrine-disrupting chemicals
V Padmanabhan, W Song… - Endocrine …, 2021 - academic.oup.com
The burden of adverse pregnancy outcomes such as preterm birth and low birth weight is
considerable across the world. Several risk factors for adverse pregnancy outcomes have …
considerable across the world. Several risk factors for adverse pregnancy outcomes have …