Flowing blood generates a frictional force called shear stress that has major effects on
vascular function. Branches and bends of arteries are exposed to complex blood flow …

Atherogenesis, the formation of atherosclerotic plaques, is a complex process that involves
several mechanisms, including endothelial dysfunction, neovascularization, vascular …

Aging is associated with a progressive decline in cardiovascular structure and function.
Accumulating evidence links cardiovascular aging to epigenetic alterations encompassing a …

Atherosclerosis is a vascular pathology characterized by inflammation and plaque build-up
within arterial vessel walls. Vessel occlusion, often occurring after plaque rupture, can result …

Gene expression in mammalian cells depends on the epigenetic status of the chromatin,
including DNA methylation, histone modifications, promoter–enhancer interactions, and …

Cardiovascular diseases are the number one cause of death worldwide and greatly impact
quality of life and medical costs. Enormous effort has been made in research to obtain new …

Mortality and morbidity from cardiovascular diseases (CVDs) represents a huge burden to
society. It is recognized that environmental factors and individual lifestyles play important …

A number of human diseases, such as arthritis and atherosclerosis, include characteristic
pathology in specific anatomical locations. Here we show transcriptomic differences in …

The study of cerebral microvessels is becoming increasingly important in a wide variety of
conditions, such as stroke, sepsis, traumatic brain injury and neurodegenerative diseases …

Epigenetics is a rapidly growing field of biology that studies the changes in gene expression
that are not due to alterations in the DNA sequence but rather the chemical modifications of …