Critical roles of protein arginine methylation in the central nervous system
K Chang, D Gao, J Yan, L Lin, T Cui, S Lu - Molecular Neurobiology, 2023 - Springer
A remarkable post-transitional modification of both histones and non-histone proteins is
arginine methylation. Methylation of arginine residues is crucial for a wide range of cellular …
arginine methylation. Methylation of arginine residues is crucial for a wide range of cellular …
Recent advances in targeting protein arginine methyltransferase enzymes in cancer therapy
Introduction: Exploration in the field of epigenetics has revealed the diverse roles of the
protein arginine methyltransferase (PRMT) family of proteins in multiple disease states …
protein arginine methyltransferase (PRMT) family of proteins in multiple disease states …
PRMT8 attenuates cerebral ischemia/reperfusion injury via modulating microglia activation and polarization to suppress neuroinflammation by upregulating Lin28a
K Zheng, Y Zhang, C Zhang, W Ye, C Ye… - ACS Chemical …, 2022 - ACS Publications
Activation and polarization of microglia are involved in neuroinflammation and regulate
ischemic stroke-associated brain injury. Protein arginine methyltransferase 8 functions as a …
ischemic stroke-associated brain injury. Protein arginine methyltransferase 8 functions as a …
PRMT8 as a phospholipase regulates Purkinje cell dendritic arborization and motor coordination
The development of vertebrate neurons requires a change in membrane
phosphatidylcholine (PC) metabolism. Although PC hydrolysis is essential for enhanced …
phosphatidylcholine (PC) metabolism. Although PC hydrolysis is essential for enhanced …
Protein arginine methyltransferases in cardiovascular and neuronal function
A Couto e Silva, CYC Wu, CT Citadin… - Molecular …, 2020 - Springer
The methylation of arginine residues by protein arginine methyltransferases (PRMTs) is a
type of post-translational modification which is important for numerous cellular processes …
type of post-translational modification which is important for numerous cellular processes …
Activity and function of the PRMT8 protein arginine methyltransferase in neurons
Among the nine mammalian protein arginine methyltransferases (PRMTs), PRMT8 is
unusual because it has restricted expression in the nervous system and is the only …
unusual because it has restricted expression in the nervous system and is the only …
Automethylation of protein arginine methyltransferase 8 (PRMT8) regulates activity by impeding S-adenosylmethionine sensitivity
MBC Dillon, HL Rust, PR Thompson… - Journal of Biological …, 2013 - ASBMB
Protein arginine methyltransferase (PRMT) 8 is unique among the PRMTs, as it has a highly
restricted tissue expression pattern and an N terminus that contains two automethylation …
restricted tissue expression pattern and an N terminus that contains two automethylation …
PRMT1 and PRMT8 regulate retinoic acid-dependent neuronal differentiation with implications to neuropathology
Retinoids are morphogens and have been implicated in cell fate commitment of embryonic
stem cells (ESCs) to neurons. Their effects are mediated by RAR and RXR nuclear …
stem cells (ESCs) to neurons. Their effects are mediated by RAR and RXR nuclear …
Methylation determines the extracellular calcium sensitivity of the leak channel NALCN in hippocampal dentate granule cells
The sodium leak channel NALCN is a key player in establishing the resting membrane
potential (RMP) in neurons and transduces changes in extracellular Ca2+ concentration …
potential (RMP) in neurons and transduces changes in extracellular Ca2+ concentration …
Arginine methylation in brain tumors: Tumor biology and therapeutic strategies
Protein arginine methylation is a common post-translational modification that plays a pivotal
role in cellular regulation. Protein arginine methyltransferases (PRMTs) catalyze the …
role in cellular regulation. Protein arginine methyltransferases (PRMTs) catalyze the …