IRAK1 and IRAK4 as emerging therapeutic targets in hematologic malignancies

J Bennett, DT Starczynowski - Current Opinion in Hematology, 2022 - journals.lww.com
IRAK-targeted therapies that have matriculated to early phase trials are yielding promising
preliminary results. However, studies of IRAK kinase signaling continue to defy conventional …

Circulating tumor DNA detection: A potential tool for colorectal cancer management

H Li, C Jing, J Wu, J Ni, H Sha, X Xu… - Oncology …, 2019 - spandidos-publications.com
Colorectal cancer (CRC) is frequently diagnosed at an advanced stage of the disease, the
pathogenesis of which is influenced by genetic and epigenetic events. Circulating tumor …

Peptides and combination of peptides for use in immunotherapy against small cell lung cancer and other cancers

M Andrea, T Weinschenk, V Goldfinger… - US Patent …, 2019 - Google Patents
The present invention relates to peptides, proteins, nucleic acids and cells for use in
immunotherapeutic methods. In particular, the present invention relates to the immuno …

Peptides and combination of peptides for use in immunotherapy against small cell lung cancer and other cancers

A Mahr, T Weinschenk, V Goldfinger, O Schoor… - 2018 - Google Patents
ZRKFYGHZFMAOKI-QMGMOQQFSA-N tgfbeta Chemical compound C ([C@ H](NC (=
O)[C@ H](C (C) C) NC (= O) CNC (= O)[C@ H](CCC (O)= O) NC (= O)[C@ H](CCCNC (N) …

DDX1 is a prognostic biomarker and correlates with immune infiltrations in hepatocellular carcinoma

M Yuan, J Xu, S Cao, S Sun - BMC immunology, 2022 - Springer
Hepatocellular carcinoma (HCC) is one of the leading lethal malignant tumors worldwide.
DEAD-box (DDX) family helicases are implicated in numerous human cancers. However …

Integrative multi-platform meta-analysis of gene expression profiles in pancreatic ductal adenocarcinoma patients for identifying novel diagnostic biomarkers

A Irigoyen, C Jimenez-Luna, M Benavides, O Caba… - PLoS …, 2018 - journals.plos.org
Applying differentially expressed genes (DEGs) to identify feasible biomarkers in diseases
can be a hard task when working with heterogeneous datasets. Expression data are strongly …

The mechanistic, diagnostic and therapeutic novel nucleic acids for hepatocellular carcinoma emerging in past score years

S Zhang, Y Zhou, Y Wang, Z Wang… - Briefings in …, 2021 - academic.oup.com
Abstract Despite The Central Dogma states the destiny of gene as 'DNA makes RNA and
RNA makes protein', the nucleic acids not only store and transmit genetic information but …

[HTML][HTML] The potential of liquid biopsies in gastrointestinal cancer

C Wu, J Zhang, H Li, W Xu, X Zhang - Clinical Biochemistry, 2020 - Elsevier
Background Liquid biopsy is a novel approach for cancer diagnosis, the value of which in
human gastrointestinal (GI) cancer has been confirmed by the previous studies. This article …

Retracted: IRAK3 gene silencing prevents cardiac rupture and ventricular remodeling through negative regulation of the NF‐κB signaling pathway in a mouse model …

ZW Ge, BC Wang, JL Hu, JJ Sun… - Journal of cellular …, 2019 - Wiley Online Library
Cardiac rupture and ventricular remodeling are recognized as the severe complications and
major risk factors of acute myocardial infarction (AMI). This study aims to evaluate the …

IL-1 receptor-associated kinase family proteins: An overview of their role in liver disease

Z Wang, S Gao, X Gou, F Qiu, Q Feng - European Journal of Pharmacology, 2024 - Elsevier
Abstract 1 The interleukin-1 receptor-associated kinase (IRAK) family is a group of serine-
threonine kinases that regulates various cellular processes via toll-like receptor …