In the burgeoning field of epigenetics, there are several methods available to determine the
methylation status of DNA samples. However, choosing the method that is best suited to …

Acute myeloid leukemia (AML) is the most common acute leukemia in adults. The
pathophysiology of this disease is just beginning to be understood at the cellular and …

Here, we present a practical overview of four commonly used validation methods for DNA
methylation assessment: methylation specific restriction endonucleases (MSRE) analysis …

Major histocompatibility complex (MHC) molecules are key players in initiating immune
responses towards invading pathogens. Both MHC class I and class II genes are present in …

Dementia is a major public health issue with rising prevalence rates, but many individuals
remain undiagnosed. Accurate and timely diagnosis is key for the optimal targeting of …

Biomarkers are valuable tools in clinical practice. In 2001, the National Institutes of Health
(NIH) standardized the definition of a biomarker as a characteristic that is objectively …

Objective Asthma is a common chronic respiratory airway disease influenced by
environmental factors and possibly their interaction with the human genome causing …

Epigenetic mechanisms have been suggested to play a role in the genetic regulation of
pathways related to inflammation. Therefore, we aimed to systematically review studies …

Cancer metastasis is the main reason for the high mortality in patients, contributing to 90% of
cancer-related deaths. Biomarkers for early detection and therapeutic monitoring are …

Assessing DNA methylation profiles in human blood has become a major focus of
epidemiologic inquiry. Understanding variability in CpG-specific DNA methylation over …