In childhood, the risk for seizures is greatest in the neonatal period. Currently used therapies
have limited efficacy. Although the treatment of neonatal seizures has not significantly …

Neonatal seizures are an important example of an age-specific seizure syndrome.
Compared with seizures at older ages, neonatal seizures differ in etiology, semiology, and …

Tetraspanins (Tspans) are a family of four-span transmembrane proteins, known as plasma
membrane “master organizers.” They form Tspan-enriched microdomains (TEMs or TERMs) …

Seizures induce excitatory shifts in the reversal potential for GABAA-receptor-mediated
responses, which may contribute to the intractability of electro-encephalographic seizures …

Abstract Background Continuous EEG monitoring (cEEG) of critically ill patients is frequently
utilized to detect non-convulsive seizures (NCS) and status epilepticus (NCSE). The …

Neonates are at especially high risk for seizures as compared to other age groups. 1 The
high risk for seizures—and especially acute symptomatic seizures—is likely multifactorial …

Objective: Drug exposure during critical periods of brain development may adversely affect
nervous system function, posing a challenge for treating infants. This is of particular concern …

PURPOSE: Neonatal seizures are common, especially in prematurity. Phenobarbital (PB)
currently represents the antiepileptic drug (AED) of choice, despite being related to …

BACKGROUND: The impact of treating electrographic seizures in hypoxic ischemic
encephalopathy (HIE) is unknown. METHODS: Neonates≥ 36 weeks with moderate or …

Neonatal seizures are often refractory to treatment with initial antiseizure medications.
Consequently, clinicians turn to alternatives such as levetiracetam, despite the lack of …