Mesenchymal stem cells (MSCs) have regenerative, immunoregulatory properties and can
be easily isolated and expanded in vitro. Despite being a powerful tool for clinical …

Brain-derived neurotrophic factor (BDNF) is one of the most studied neurotrophins in the
mammalian brain, essential not only to the development of the central nervous system but …

Rett syndrome is an X-linked autism spectrum disorder. The disease is characterized in most
cases by mutation of the MECP2 gene, which encodes a methyl-CpG-binding protein …

Regulation of neuronal gene expression is critical to central nervous system development.
Here, we show that REST regulates the transitions from pluripotent to neural stem/progenitor …

Cytosine methylation in CpG dinucleotides is believed to be important in gene regulation,
and is generally associated with reduced levels of transcription. Methylation-mediated gene …

DNA methylation is a stable but not irreversible epigenetic signal that silences gene
expression. It has a variety of important functions in mammals, including control of gene …

Nervous system development relies on a complex signaling network to engineer the orderly
transitions that lead to the acquisition of a neural cell fate. Progression from the non …

Common themes are emerging in the molecular mechanisms of long non‐coding RNA‐
mediated gene repression. Long non‐coding RNAs (lncRNAs) participate in targeted gene …

Although high levels of 5-hydroxymethylcytosine (5hmC) accumulate in mammalian
neurons, our knowledge of its roles in terminal differentiation or as an intermediate in active …

A dysfunction of cortical and limbic GABAergic circuits has been postulated to contribute to
multiple neurodevelopmental disorders in humans, including schizophrenia, autism, and …