The basic body plan of the mammalian embryo is established through gastrulation, a pivotal
early postimplantation event during which the three major germ layers (endoderm …

Recent advances in methods to culture pluripotent stem cells to model human development
have resulted in entities that increasingly have recapitulated advanced stages of early …

Recently, 2 branches of the wide area of synthetic biology—in vitro gametogenesis and
synthetic embryo development—have gained considerable attention. Rodent induced …

OBJECTIVE: Several studies have shown higher pregnancy rates and better perinatal
outcomes with frozen embryo transfers than with fresh techniques, with better results in …

Objective To present the ethical issues, moral arguments, and reasons found in the ethical
literature on organoid models. Design In this systematic review of reasons in ethical …

Ethical considerations are central to all medicine though, likely, nowhere more essential
than in the practice of reproductive endocrinology and infertility. Through in vitro fertilization …

Cerebral organoid models in-of-themselves are considered as an alternative to research
animal models. But their developmental and biological limitations currently inhibit the …

The experimental production of complex structures resembling mammalian embryos (eg,
blastoids, gastruloids) from pluripotent stem cells in vitro has become a booming research …

Human development is a highly coordinated process, with any abnormalities during the
early embryonic stages that can often have detrimental consequences. The complexity and …

Molecular mechanisms surrounding early human embryonic events such as blastocyst
formation, implantation, and the specification of the body axes are some of the most …