Hematopoietic stem cell transplantation-associated thrombotic microangiopathy and the role of advanced practice providers and pharmacists

Z Mahmoudjafari, MC Alencar, MD Alexander… - Bone Marrow …, 2023 - nature.com
Hematopoietic stem cell transplantation-associated thrombotic microangiopathy (HSCT-
TMA) is a severe and potentially life-threatening complication. HSCT-TMA is often …

Reeling in complement in transplant‐associated thrombotic microangiopathy: You're going to need a bigger boat

S Jodele, A Sabulski - American Journal of Hematology, 2023 - Wiley Online Library
Over the last decade there have been numerous advances in both the diagnosis and
treatment of transplant‐associated thrombotic microangiopathy (TA‐TMA). These are largely …

D‐dimer and sinusoidal obstructive syndrome‐novel poor prognostic features of thrombotic microangiopathy in children after hematopoietic cellular therapy in a single …

ML Schoettler, K French, A Harris… - American Journal of …, 2024 - Wiley Online Library
Transplant‐associated thrombotic microangiopathy (TA‐TMA) is a common, severe
complication of allogeneic hematopoietic cellular therapy (HCT). Even when treated in many …

Molecular advances in sinusoidal obstruction syndrome/Veno-occlusive disease

I Mavrikou, D Chatzidimitriou, L Skoura… - International Journal of …, 2023 - mdpi.com
Sinusoidal obstruction syndrome/veno-occlusive disease (SOS/VOD) detected in the liver
has been considered a severe complication of hematopoietic stem cell transplantation …

Adopting Model‐Informed Precision‐Dosing for Eculizumab in Transplant Associated‐Thrombotic Microangiopathy to Gene Therapies

S Jodele, K Mizuno, A Sabulski… - Clinical Pharmacology & …, 2023 - Wiley Online Library
Gene therapy advances offer great hope to previously uncurable disorders but come with a
steep learning curve to assure safety and therapeutic success. Thrombotic microangiopathy …

TCRαβ/CD19 cell–depleted HLA-haploidentical transplantation to treat pediatric acute leukemia: updated final analysis

P Merli, M Algeri, F Galaverna, V Bertaina, B Lucarelli… - Blood, 2024 - ashpublications.org
TCRαβ/CD19 cell depletion is a promising graft manipulation technique frequently used in
the context of human leukocyte antigen (HLA)–haploidentical hematopoietic stem cell …

MASP2 inhibition by narsoplimab suppresses endotheliopathies characteristic of transplant-associated thrombotic microangiopathy: in vitro and ex vivo evidence

S Elhadad, D Redmond, J Huang, A Tan… - Clinical and …, 2023 - academic.oup.com
Transplant-associated thrombotic microangiopathy (TA-TMA) is an endotheliopathy
complicating up to 30% of allogeneic hematopoietic stem cell transplants (alloHSCT) …

[HTML][HTML] Neurologic complications of the central nervous system after allogeneic stem cell transplantation: the role of transplantation-associated thrombotic …

E Sala, AM Neagoie, J Lewerenz, M Saadati… - … and Cellular Therapy, 2024 - Elsevier
Neurologic complications (NCs), especially those of the central nervous system (CNS),
represent a severe complication after allogeneic stem cell transplantation (allo-HSCT) and …

Early response markers predict survival after etoposide-based therapy of hemophagocytic lymphohistiocytosis

B Verkamp, A Zoref-Lorenz, B Francisco… - Blood …, 2023 - ashpublications.org
Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening hyperinflammatory
syndrome that is most commonly treated with etoposide and dexamethasone. This standard …

[HTML][HTML] Incidence and role of recipient-specific antibodies in allogeneic hematopoietic cell transplantation from mismatched related donors

A Sadowska-Klasa, A Dukat-Mazurek… - … and Cellular Therapy, 2024 - Elsevier
High titer of donor-specific antibodies (DSAs) increases the risk of graft rejection after
mismatched related hematopoietic cell transplantation (HCT). There are no data regarding …