Kanwal R, Gupta S. Epigenetic modifications in cancer. Cancer initiation and progression is
controlled by both genetic and epigenetic events. The complexity of carcinogenesis cannot …

Abstract Aflatoxin B1 (AFB1) is widely distributed in nature, especially in a variety of food
commodities. It is confirmed to be the most toxic of all the aflatoxins. The toxicity of AFB1 has …

Although epidemiological studies support the role of environment in a wide range of human
cancers, the precise mechanisms by which environmental exposures promote cancer …

Background: Blood leukocytes from patients with solid tumors exhibit complex and distinct
cancer-associated patterns of DNA methylation. However, the biologic mechanisms …

Background Aberrant methylation of the global genome has been investigated as a
prognostic indicator in various cancers, but the results are controversial and ambiguous …

Background The rapid development of programmed death 1 (PD-1)/programmed death
ligand 1 (PD-L1) inhibitors has generated an urgent need for biomarkers assisting the …

Colorectal cancer is the third most common cancer and the second leading cause of cancer-
related deaths in the United States. Screening has been shown to be effective in reducing …

RASSF1A, one of the eight isoforms of the RASSF1 gene, is a tumor suppressor gene that
influences tumor initiation and development. In cancer, RASSF1A is frequently inactivated …

Epigenetics is the study of inherited variations in gene expression that do not involve
changes to DNA sequences. Over 200 unique cell types in a human adult have a nearly …

Malignant testicular germ cell tumors (TGCTs) are the most frequent testicular cancers in
Caucasian males, developing at the most productive age of man. We are briefly reviewing …