Transforming growth factor β (TGF-β) is a secreted cytokine that regulates cell proliferation,
migration, and the differentiation of a plethora of different cell types. Consistent with these …

Cancer cells resistance to various therapies remains to be a key challenge nowadays. For a
long time, scientists focused on tumor cells themselves for the mechanisms of acquired drug …

Background Immune checkpoint inhibitors (ICIs) have modest activity in ovarian cancer
(OC). To augment their activity, we used priming with the hypomethylating agent …

Epithelial to mesenchymal transition (EMT) occurs during the pathological process
associated with tumor progression and is considered to influence and promote the …

Tumor cells, which undergo Epithelial-mesenchymal transition (EMT) acquire increased
capacities of proliferation, invasion and have the ability to generate metastases by escaping …

Epithelial-to-mesenchymal transition (EMT) is a process by which cells lose their epithelial
characteristics and gain mesenchymal phenotypes. In cancer, EMT is thought to drive tumor …

Close proximity between cytotoxic T lymphocytes and tumour cells is required for effective
immunotherapy. However, what controls the spatial distribution of T cells in the tumour …

Alcoholic hepatitis (AH) is a life-threatening condition characterized by profound
hepatocellular dysfunction for which targeted treatments are urgently needed. Identification …

DNA methylation plays a pivotal role in the etiology of cancer by mediating epigenetic
silencing of cancer-related genes. Since the relationship between aberrant DNA methylation …

Nitric oxide (NO) in general plays a beneficial physiological role as a vasorelaxant and the
role of NO is decided by its concentration present in physiological environments. NO either …