Flow-induced, inflammation-mediated arterial wall remodeling in the formation and progression of intracranial aneurysms

J Frösen, J Cebral, AM Robertson, T Aoki - Neurosurgical focus, 2019 - thejns.org
OBJECTIVE Unruptured intracranial aneurysms (UIAs) are relatively common lesions that
may cause devastating intracranial hemorrhage, thus producing considerable suffering and …

The biophysical role of hemodynamics in the pathogenesis of cerebral aneurysm formation and rupture

S Soldozy, P Norat, M Elsarrag, A Chatrath… - Neurosurgical …, 2019 - thejns.org
The pathogenesis of intracranial aneurysms remains complex and multifactorial. While
vascular, genetic, and epidemiological factors play a role, nascent aneurysm formation is …

Prostaglandin E2–EP2–NF-κB signaling in macrophages as a potential therapeutic target for intracranial aneurysms

T Aoki, J Frȍsen, M Fukuda, K Bando, G Shioi… - Science …, 2017 - science.org
Intracranial aneurysms are common but are generally untreated, and their rupture can lead
to subarachnoid hemorrhage. Because of the poor prognosis associated with subarachnoid …

Vessel wall enhancement in unruptured intracranial aneurysms: an indicator for higher risk of rupture? High-resolution MR imaging and correlated histologic findings

N Larsen, C Von Der Brelie, D Trick… - American Journal …, 2018 - Am Soc Neuroradiology
BACKGROUND AND PURPOSE: Recent studies have suggested that wall enhancement of
unruptured intracranial aneurysms in high-resolution MR imaging might serve as an imaging …

What does computational fluid dynamics tell us about intracranial aneurysms? A meta-analysis and critical review

KM Saqr, S Rashad, S Tupin… - Journal of Cerebral …, 2020 - journals.sagepub.com
Despite the plethora of published studies on intracranial aneurysms (IAs) hemodynamic
using computational fluid dynamics (CFD), limited progress has been made towards …

Local hemodynamic conditions associated with focal changes in the intracranial aneurysm wall

JR Cebral, F Detmer, BJ Chung… - American Journal …, 2019 - Am Soc Neuroradiology
BACKGROUND AND PURPOSE: Aneurysm hemodynamics has been associated with wall
histology and inflammation. We investigated associations between local hemodynamics and …

Role of hemodynamics in initiation/growth of intracranial aneurysms

MR Diagbouga, S Morel, P Bijlenga… - European journal of …, 2018 - Wiley Online Library
Background Intracranial aneurysm (IA) is a disease of the vascular wall resulting in
abnormal enlargement of the vessel lumen. It is a common pathology with a prevalence of …

Risk factors for hemorrhage of brain arteriovenous malformation

SS Shaligram, E Winkler, D Cooke… - CNS neuroscience & …, 2019 - Wiley Online Library
Patients with brain arteriovenous malformation (bAVM) are at risk of intracranial hemorrhage
(ICH). Overall, bAVM accounts for 25% of hemorrhagic strokes in adults< 50 years of age …

[HTML][HTML] Imaging modalities for intracranial aneurysm: more than meets the eye

C Maupu, H Lebas, Y Boulaftali - Frontiers in Cardiovascular Medicine, 2022 - frontiersin.org
Intracranial aneurysms (IA) are often asymptomatic and have a prevalence of 3 to 5% in the
adult population. The risk of IA rupture is low, however when it occurs half of the patients …

[HTML][HTML] Fluid–structure interaction (FSI) simulation for studying the impact of atherosclerosis on hemodynamics, arterial tissue remodeling, and initiation risk of …

AA Rostam-Alilou, HR Jarrah, A Zolfagharian… - … and modeling in …, 2022 - Springer
The biomechanical and hemodynamic effects of atherosclerosis on the initiation of
intracranial aneurysms (IA) are not yet clearly discovered. Also, studies for the observation of …