Metabolic disorders are increasingly prevalent worldwide, leading to high rates of morbidity
and mortality. The variety of metabolic illnesses can be addressed through personalized …

NEDD8 (Neural precursor cell expressed developmentally downregulated protein 8) is an
ubiquitin-like protein that is covalently attached to a lysine residue of a protein substrate …

Epigenetic dysregulation emerges as a critical hallmark and driving force of aging. Although
still an evolving field with much to explore, it has rapidly gained significance by providing …

Alarming statistics show that the number of people affected by excessive weight has
surpassed 2 billion, representing approximately 30% of the world's population. The aim of …

Medial arterial calcification (MAC), a systemic vascular disease different from
atherosclerosis, is associated with an increased incidence of cardiovascular events. Several …

The transcription factor HOXA5, from the HOX gene family, has long been studied due to its
critical role in physiological activities in normal cells, such as organ development and body …

Metabolic diseases and their complications impose health and economic burdens
worldwide. Evidence from past experimental studies and clinical trials suggests our body …

Osteoporosis (OP) is a prevalent age-related disease that is characterized by a decrease in
bone mineral density (BMD) and systemic bone microarchitectural disorders. With age …

Metabolic dysfunction-associated steatotic fatty liver disease (MASLD), a novel definition for
NAFLD, represents one of the most common causes of liver disease, and its incidence is …

Metabolic dysfunction-associated steatotic liver disease (MASLD) encompasses a wide
spectrum of liver injuries, ranging from hepatic steatosis, metabolic dysfunction-associated …