The role of crosstalk between adipose cells and myocytes in the pathogenesis of sarcopenic obesity in the elderly

M Zamboni, G Mazzali, A Brunelli, T Saatchi, S Urbani… - Cells, 2022 - mdpi.com
As a result of aging, body composition changes, with a decline in muscle mass and an
increase in adipose tissue (AT), which reallocates from subcutaneous to visceral depots and …

Slow or fast: Implications of myofibre type and associated differences for manifestation of neuromuscular disorders

EM Lloyd, GJ Pinniger, RM Murphy… - Acta …, 2023 - Wiley Online Library
Many neuromuscular disorders can have a differential impact on a specific myofibre type,
forming the central premise of this review. The many different skeletal muscles in mammals …

Converging protective pathways: Exploring the linkage between physical exercise, extracellular vesicles and oxidative stress

V Lisi, G Senesi, C Balbi - Free Radical Biology and Medicine, 2023 - Elsevier
Physical Exercise (EXR) has been shown to have numerous beneficial effects on various
systems in the human body. It leads to a decrease in the risk of mortality from chronic …

Rejuvenation: turning back time by enhancing CISD2

CH Yeh, ZQ Shen, CC Lin, CK Lu, TF Tsai - International Journal of …, 2022 - mdpi.com
The aging human population with age-associated diseases has become a problem
worldwide. By 2050, the global population of those who are aged 65 years and older will …

Physiological approaches targeting cellular and mitochondrial pathways underlying adipose organ senescence

P de Lange, A Lombardi, E Silvestri, F Cioffi… - International Journal of …, 2023 - mdpi.com
The adipose organ is involved in many metabolic functions, ranging from the production of
endocrine factors to the regulation of thermogenic processes. Aging is a natural process that …

[HTML][HTML] Exercise couples mitochondrial function with skeletal muscle fiber type via ROS-mediated epigenetic modification

J Li, Z Zhang, H Bo, Y Zhang - Free Radical Biology and Medicine, 2024 - Elsevier
Skeletal muscle is a heterogeneous tissue composed of different types of muscle fibers,
demonstrating substantial plasticity. Physiological or pathological stimuli can induce …

Probiotics and commensal bacteria metabolites trigger epigenetic changes in the gut and influence beneficial mood dispositions

L Vitetta, M Bambling, E Strodl - Microorganisms, 2023 - mdpi.com
The effect of the intestinal microbiome on the gut–brain axis has received considerable
attention, strengthening the evidence that intestinal bacteria influence emotions and …

Aerobic exercise mitigates hippocampal neuronal apoptosis by regulating DAPK1/CDKN2A/REDD1/FoXO1/FasL signaling pathway in D‐galactose‐induced aging …

Y Liu, W Guo, SL Hong - The FASEB Journal, 2023 - Wiley Online Library
Brain aging is the most important risk factor for neurodegenerative disorders, and abnormal
apoptosis is linked to neuronal dysfunction. Specifically, studies have found that exercise …

Endurance exercise-induced histone methylation modification involved in skeletal muscle fiber type transition and mitochondrial biogenesis

J Li, S Zhang, C Li, X Zhang, Y Shan, Z Zhang, H Bo… - Scientific Reports, 2024 - nature.com
Skeletal muscle is a highly heterogeneous tissue, and its contractile proteins are composed
of different isoforms, forming various types of muscle fiber, each of which has its own …

Exercise Epigenetics is fueled by cell Bioenergetics: Supporting role on Brain Plasticity and Cognition

F Gomez-Pinilla, P Thapak - Free Radical Biology and Medicine, 2024 - Elsevier
Exercise has the unique aptitude to benefit overall health of body and brain. Evidence
indicates that the effects of exercise can be saved in the epigenome for considerable time to …