We have reviewed the literature and have identified more than 100 diseases or conditions
that are associated with raised concentrations of plasma total homocysteine. The …

The B-vitamins comprise a group of eight water soluble vitamins that perform essential,
closely inter-related roles in cellular functioning, acting as co-enzymes in a vast array of …

Identification of modifiable risk factors provides a crucial approach to the prevention of
dementia. Nutritional or nutrient-dependent risk factors are especially important because …

This report on vitamin B-12 (B12) is part of the Biomarkers of Nutrition for Development
(BOND) Project, which provides state-of-the art information and advice on the selection, use …

Moderately elevated plasma total homocysteine (tHcy) is a strong modifiable risk factor for
vascular dementia and Alzheimer's disease. Prospectively, elevated tHcy is associated with …

Stroke is a primary debilitating disease in adults, occurring in 15 million individuals each
year and causing high mortality and disability rates. The latest estimate revealed that stroke …

The biosynthesis of B 12, involving up to 30 different enzyme-mediated steps, only occurs in
bacteria. Thus, most eukaryotes require an external source of B 12, and yet the vitamin …

Abstract Context Elevation of homocysteine (Hcy) levels is well-established as a risk factor
for dementia, yet controversy exists regarding whether B-vitamin-mediated reduction of …

Objectives To evaluate the combined action of folic acid and vitamin B12 supplementation
on cognitive performance and inflammation in patients with Alzheimer's disease (AD) …

Mild cognitive impairment (MCI) is defined as an intermediate state between normal
cognitive aging and dementia. It describes a status of the subjective impression of cognitive …