Remarkable progress in ageing research has been achieved over the past decades.
General perceptions and experimental evidence pinpoint that the decline of physical …

Epigenetic clocks comprise a set of CpG sites whose DNA methylation levels measure
subject age. These clocks are acknowledged as a highly accurate molecular correlate of …

Bone defects stand out as one of the greatest challenges of reconstructive surgery. Fused
deposition modelling (FDM) allows for the printing of 3D scaffolds tailored to the morphology …

Background Human aging is associated with DNA methylation changes at specific sites in
the genome. These epigenetic modifications may be used to track donor age for forensic …

Numerous studies have shown that epigenetic age—an individual's degree of aging based
on patterns of DNA methylation—can be computed and is associated with an array of factors …

Understanding the role of epigenetic modifications, eg DNA methylation, in the process of
aging requires the characterization of methylation patterns in large cohorts. We analysed> …

Over the past decades, mesenchymal stem cell (MSC)-based therapy has been intensively
investigated and shown promising results in the treatment of various diseases due to their …

Ageing is influenced by the intrinsic disposition delineating what is maximally possible and
extrinsic factors determining how that frame is individually exploited. Intrinsic and extrinsic …

Background The well-established association of chronological age with changes in DNA
methylation is primarily founded on the analysis of large sets of blood samples, while …

Standardization of mesenchymal stromal cells (MSCs) remains a major obstacle in
regenerative medicine. Starting material and culture expansion affect cell preparations and …