The concept of induced protein degradation by small molecules has emerged as a
promising therapeutic strategy that is particularly effective in targeting proteins previously …

In cancer patients, immune cells are often functionally compromised due to the
immunosuppressive features of the tumor microenvironment (TME) which contribute to the …

Cancer cell invasion, intravasation and survival in the bloodstream are early steps of the
metastatic process, pivotal to enabling the spread of cancer to distant tissues. Circulating …

Simple Summary Cancer represents unrestricted growth with the removal of conventional
brakes that control growth under normal conditions. This requires novel mechanisms to …

Renal cell carcinoma (RCC) represents 85–95% of kidney cancers and is the most frequent
type of renal cancer in adult patients. It accounts for 3% of all cancer cases and is in 7th …

Abstract The Von Hippel–Lindau (VHL) protein, which is frequently mutated in clear-cell
renal cell carcinoma (ccRCC), is a master regulator of hypoxia-inducible factor (HIF) that is …

Hypoxia-inducible factor-1α (HIF-1α) constitutes the principal mediator of cellular adaptation
to hypoxia in humans. The HIF-1α protein level and activity are tightly regulated by the …

Background Hyaluronic acid (HA) promotes cancer metastasis; however, the currently
approved treatments do not target HA. Metastatic renal carcinoma (mRCC) is an incurable …

The scientific community has shown considerable interest in proteolysis-targeting chimeras
(PROTACs) in the last decade, indicating their remarkable potential as a means of achieving …

Renal fibrosis is the final stage of most progressive kidney diseases. Chronic kidney disease
(CKD) is associated with high comorbidity and mortality. Thus, preventing fibrosis and …