There is a growing understanding that pathological genetic variation and environmental
insults during sensitive periods in brain development have long-term consequences on …

Mutations in methyl CpG binding protein 2 (MeCP2) are the major cause of Rett syndrome
(RTT), a rare neurodevelopmental disorder with a notable period of developmental …

Rett syndrome (RTT) is a neurological disorder caused by mutations in the X-linked gene
methyl-CpG-binding protein 2 (MECP2), a ubiquitously expressed transcriptional regulator …

Lying at the intersection between neurobiology and epigenetics, Rett syndrome (RTT) has
garnered intense interest in recent years, not only from a broad range of academic scientists …

Rett Syndrome (RTT) is a severe, rare, and progressive developmental disorder with
patients displaying neurological regression and autism spectrum features. The affected …

Methyl-CpG-binding protein 2 (MeCP2) is a transcriptional regulator that is highly abundant
in the brain. It binds to methylated genomic DNA to regulate a range of physiological …

Epigenetic modifications, including DNA methylation, histone modifications, and non-coding
RNAs, have been implicated in a number of complex diseases. Schizophrenia and other …

The X-linked neurological disorder Rett syndrome (RTT) presents with autistic features and
is caused primarily by mutations in a transcriptional regulator, methyl CpG–binding protein 2 …

Background MeCP2—a chromatin-binding protein associated with Rett syndrome—has two
main isoforms, MeCP2-E1 and MeCP2-E2, differing in a few N-terminal amino acid residues …

The role of sex as an effect modifier of developmental lead (Pb) exposure has until recently
received little attention. Lead exposure in early life can affect brain development with …