Ancestral environmental exposures such as toxicants, abnormal nutrition or stress can
promote the epigenetic transgenerational inheritance of disease and phenotypic variation …

BACKGROUND A defining feature of sexual reproduction is the transmission of genomic
information from both parents to the offspring. There is now compelling evidence that the …

INTRODUCTION Despite the father transmitting half of the heritable information to the
embryo, the focus of preconception health has been the mother. Paternal effects have been …

Ancestral environmental exposures to a variety of factors and toxicants have been shown to
promote the epigenetic transgenerational inheritance of adult onset disease. One of the …

Leptin is an adipocyte-secreted hormone that inhibits food intake and stimulates energy
expenditure through interactions with neuronal pathways in the brain, particularly pathways …

Background Environmental toxicants such as DDT have been shown to induce the
epigenetic transgenerational inheritance of disease (eg, obesity) through the germline. The …

The idea that inherited genotypes define phenotypes has been paramount in modern
biology. The question remains, however, whether stable phenotypes could be also inherited …

Genome-wide DNA methylation analysis is one of the most common epigenetic processes
analysed for genome characterization and differential DNA methylation assessment …

Ancestral environmental exposures to a variety of environmental toxicants and other factors
have been shown to promote the epigenetic transgenerational inheritance of adult onset …

Environmental factors can promote phenotypic variation through alterations in the
epigenome and facilitate adaptation of an organism to the environment. Although hydrogen …