Advances in our understanding of how the gut microbiota contributes to human health and
diseases have expanded our insight into how microbial composition and function affect the …

Morbidity and mortality of cardiovascular diseases (CVDs) are exceedingly high worldwide.
Researchers have found that the occurrence and development of CVDs are closely related …

Objective: Gut microbial metabolism of dietary choline, a nutrient abundant in a Western diet,
produces trimethylamine (TMA) and the atherothrombosis-and fibrosis-promoting metabolite …

Elevated circulating concentrations of the gut bacteria choline metabolite trimethylamine N‐
oxide (TMAO) were found in patients with type 2 diabetes mellitus (T2DM). However …

The gut microbial metabolite trimethylamine N-oxide (TMAO) is increasingly regarded as a
novel risk factor for cardiovascular events and mortality. However, little is known about the …

Abstract Purpose of Review The association between plasma Trimethylamine N-Oxide
(TMAO), diet and risk for cardiovascular disease (CVD) is still not fully understood. While …

It has been suggested that trimethylamine N‐oxide (TMAO) is associated with increased risk
of diabetes and cardiovascular disease (CVD) morbidity and mortality. However, it is not …

In chronic kidney disease (CKD), accumulation of uremic toxins is associated with an
increased risk of CKD progression. Some uremic toxins result from nutrient processing by …

ABSTRACT Background Trimethylamine-N-oxide (TMAO) is a gut microbiota–derived
metabolite produced from dietary nutrients. Many studies have discovered that circulating …

Chronic kidney disease (CKD) is an increasing global health burden. Current treatments for
CKD include therapeutics to target factors that contribute to CKD progression, including …