Plasma trimethylamine-N-oxide, its precursors and risk of cardiovascular events in patients with acute coronary syndrome: mediating effects of renal function

R Sanchez-Gimenez, OM Peiro, G Bonet… - Frontiers in …, 2022 - frontiersin.org
Aims To examine associations of the gut microbial metabolite trimethylamine-N-oxide
(TMAO) and its precursors with risk of cardiovascular events in acute coronary syndrome …

Temporal course of plasma trimethylamine n-oxide (Tmao) levels in st-elevation myocardial infarction

MA Almesned, FM Prins, E Lipšic, MA Connelly… - Journal of Clinical …, 2021 - mdpi.com
The gut metabolite trimethylamine N-oxide (TMAO) at admission has a prognostic value in
ST-elevation myocardial infarction (STEMI) patients. However, its sequential changes and …

TMAO suppresses megalin expression and albumin uptake in human proximal tubular cells via PI3K and ERK signaling

S Kapetanaki, AK Kumawat, K Persson… - International Journal of …, 2022 - mdpi.com
Trimethylamine-N-oxide (TMAO) is a uremic toxin, which has been associated with chronic
kidney disease (CKD). Renal tubular epithelial cells play a central role in the …

An update of urine and blood metabolomics in chronic kidney disease

S Kalantari, M Nafar - Biomarkers in Medicine, 2019 - Taylor & Francis
Chronic kidney disease is considered as a serious obstacle in global health, with increasing
incidence and prevalence. In spite of numerous attempts by using recent omics …

Effect of probiotic supplementation on plasma metabolite profile after Roux-Y gastric bypass: a prospective, randomized, double-blind, placebo-controlled clinical trial

MRZ Ramos, I Felicidade, L de Oliveira Carlos… - International Journal of …, 2022 - nature.com
Background/objective There is evidence that metabolic profile changes after Roux-Y gastric
bypass (RYGB), especially due to modifications in the gastrointestinal tract. In addition …

Association of Circulating Trimethylamine N-Oxide and Its Dietary Determinants with the Risk of Kidney Graft Failure: Results of the TransplantLines Cohort Study

JL Flores-Guerrero, MCJ Osté, PB Baraldi… - Nutrients, 2021 - mdpi.com
Background. Due to the critical shortage of kidneys for transplantation, the identification of
modifiable factors related to graft failure is highly desirable. The role of trimethylamine-N …

Effect of TMAO on the incidence and prognosis of cerebral infarction: a systematic review and meta-analysis

L Wang, Y Nan, W Zhu, S Wang - Frontiers in Neurology, 2024 - frontiersin.org
Objective This study aimed to evaluate the effect of trimethylamine oxide (TMAO) on the
incidence and prognosis of cerebral infarction. Methods We searched PubMed, Embase …

Trimethylamine N-Oxide as a potential risk factor for non-communicable diseases: A systematic review

Z Hoseini-Tavassol, HS Ejtahed… - … Metabolic & Immune …, 2023 - ingentaconnect.com
Background: Trimethylamine N-Oxide (TMAO), as a gut microbiota-derived metabolite, has
been associated with a number of chronic diseases like cardiovascular diseases. Objective …

Contribution of multidrug and toxin extrusion protein 1 (MATE1) to renal secretion of trimethylamine-N-oxide (TMAO)

A Gessner, J König, MF Fromm - Scientific Reports, 2018 - nature.com
Abstract Trimethylamine-N-oxide (TMAO) gained considerable attention because of its role
as a cardiovascular risk biomarker. Organic cation transporter 2 (OCT2) mediates TMAO …

Trimethylamine N-oxide and incident atherosclerotic events in high-risk individuals with diabetes: an ACCORD trial post hoc analysis

A Cardona, A O'Brien, MC Bernier… - BMJ Open Diabetes …, 2019 - drc.bmj.com
Introduction Type 2 diabetes mellitus (T2D) confers high atherosclerotic cardiovascular
disease (ASCVD) risk. The metabolite trimethylamine N-oxide (TMAO) derived via gut flora …