Ketamine as advanced second‐line treatment in benzodiazepine‐refractory convulsive status epilepticus in children

S Buratti, E Giacheri, A Palmieri, J Tibaldi, G Brisca… - …, 2023 - Wiley Online Library
Status epilepticus (SE) is one of the most common neurological emergencies in children. To
date, there is no definitive evidence to guide treatment of SE refractory to benzodiazepines …

Treatment of pediatric convulsive status epilepticus

LL Becker, A Gratopp, C Prager, CE Elger… - Frontiers in …, 2023 - frontiersin.org
Status epilepticus is one of the most common life-threatening neurological emergencies in
childhood with the highest incidence in the first 5 years of life and high mortality and …

Preventing Long-Term Brain Damage by Nerve Agent–Induced Status Epilepticus in Rat Models Applicable to Infants: Significant Neuroprotection by Tezampanel …

MDA Furtado, V Aroniadou-Anderjaska… - … of Pharmacology and …, 2024 - ASPET
Acute exposure to nerve agents induces a peripheral cholinergic crisis and prolonged status
epilepticus (SE), causing death or long-term brain damage. To provide preclinical data …

Epilepsy: expert opinion on emerging drugs in phase 2/3 clinical trials

AW Pong, J Ross, I Tyrlikova, AJ Giermek… - Expert Opinion on …, 2022 - Taylor & Francis
Introduction Despite the existence of over 30 anti-seizure medications (ASM), including 20
over the last 30 years, a third of patients with epilepsy remain refractory to treatment, with no …

Optimal management of status epilepticus in children in the emergency setting: a review of recent advances

S Messahel, L Bracken, R Appleton - Open Access Emergency …, 2022 - Taylor & Francis
Convulsive status epilepticus (CSE) is the most common neurological emergency in children
and the second most common neurological emergency in adults. Mortality is low, but …

Transcranial photobiomodulation add-on therapy to valproic acid for pentylenetetrazole-induced seizures in peripubertal rats

CM Tsai, SF Chang, H Chang - BMC Complementary Medicine and …, 2022 - Springer
Background Convulsive status epilepticus (CSE) prevention is critical for pediatric patients
with epilepsy. Immediate intervention before CSE reduce severity. Despite its wide usage as …

Pharmacotherapy for nonconvulsive seizures and nonconvulsive status epilepticus

P Bravo, A Vaddiparti, LJ Hirsch - Drugs, 2021 - Springer
Most seizures in critically ill patients are nonconvulsive. A significant number of neurological
and medical conditions can be complicated by nonconvulsive seizures (NCSs) and …

Combined alcohol and cannabinoid exposure leads to synergistic toxicity by affecting cerebellar Purkinje cells

G Zou, J Xia, H Luo, D Xiao, J Jin, C Miao, X Zuo… - Nature …, 2022 - nature.com
Combined use of cannabis and alcohol results in greater psychoactive toxicity than either
substance alone, but the underlying central mechanisms behind this worsened outcome …

Management of neurological emergencies in children: an updated overview

M Mastrangelo, V Baglioni - Neuropediatrics, 2021 - thieme-connect.com
Neurological emergencies account for about one-third of the highest severity codes
attributed in emergency pediatric departments. About 75% of children with acute …

[HTML][HTML] Trends of anti-seizure medication use in pediatric patients in six cities in China from 2013 to 2018

L Yu, J Feng, Z Yu, H Dai - Epilepsy Research, 2020 - Elsevier
Objectives The aim of this study was to describe the prevalence of the use and prescribing
patterns of anti-seizure medications (ASMs) over a six-year period, and to provide real-world …