DNA methylation biomarkers in colorectal cancer: Clinical applications for precision medicine

N Fatemi, S Tierling, HA Es, M Varkiani… - … journal of cancer, 2022 - Wiley Online Library
Colorectal cancer (CRC) is the second leading cause of cancer death worldwide that is
attributed to gradual long‐term accumulation of both genetic and epigenetic changes. To …

Epigenetic regulation in lung cancer

S Ramazi, M Dadzadi, Z Sahafnejad, A Allahverdi - MedComm, 2023 - Wiley Online Library
Lung cancer is indeed a major cause of cancer‐related deaths worldwide. The development
of tumors involves a complex interplay of genetic, epigenetic, and environmental factors …

Comprehensive multi-omics analysis of the m7G in pan-cancer from the perspective of predictive, preventive, and personalized medicine

X Huang, Z Chen, X Xiang, Y Liu, X Long, K Li, M Qin… - EPMA Journal, 2022 - Springer
Background The N7-methylguanosine modification (m7G) of the 5′ cap structure in the
mRNA plays a crucial role in gene expression. However, the relation between m7G and …

Enlightening the path to NSCLC biomarkers: Utilizing the power of XAI-guided deep learning

K Dwivedi, A Rajpal, S Rajpal, V Kumar… - Computer Methods and …, 2024 - Elsevier
Abstract Background and Objective The early diagnosis of Non-small cell lung cancer
(NSCLC) is of prime importance to improve the patient's survivability and quality of life …

[HTML][HTML] Dysregulation of different modes of programmed cell death by epigenetic modifications and their role in cancer

R Damiescu, T Efferth, M Dawood - Cancer Letters, 2024 - Elsevier
Modifications of epigenetic factors affect our lives and can give important information
regarding one's state of health. In cancer, epigenetic modifications play a crucial role, as …

Application of deep learning in cancer epigenetics through DNA methylation analysis

M Yassi, A Chatterjee, M Parry - Briefings in bioinformatics, 2023 - academic.oup.com
DNA methylation is a fundamental epigenetic modification involved in various biological
processes and diseases. Analysis of DNA methylation data at a genome-wide and high …

[HTML][HTML] Epigallocatechin Gallate for the Treatment of Benign and Malignant Gynecological Diseases—Focus on Epigenetic Mechanisms

M Włodarczyk, M Ciebiera, G Nowicka, T Łoziński… - Nutrients, 2024 - mdpi.com
The most common malignant gynecologic diseases are cervical, uterine, ovarian, vaginal,
and vulvar cancer. Among them, ovarian cancer causes more deaths than any other cancer …

SIRT1 modifies DNA methylation linked to synaptic deficits induced by Pb in vitro and in vivo

R Wang, M Yang, Y Wu, R Liu, M Liu, Q Li, X Su… - International Journal of …, 2022 - Elsevier
To investigate the mechanism of Silent information regulator 1 (SIRT1) regulation of DNA
methylation and thus the expression of synaptic plasticity-related genes induced by lead …

[HTML][HTML] The role of novel bladder cancer diagnostic and surveillance biomarkers—what should a urologist really know?

R Malinaric, G Mantica, L Lo Monaco… - International Journal of …, 2022 - mdpi.com
The aim of this review is to analyze and describe the current landscape of bladder cancer
diagnostic and surveillance biomarkers. We researched the literature from 2016 to …

[HTML][HTML] Emerging role of different DNA methyltransferases in the pathogenesis of cancer

P Liu, F Yang, L Zhang, Y Hu, B Chen… - Frontiers in …, 2022 - frontiersin.org
DNA methylation is one of the most essential epigenetic mechanisms to regulate gene
expression. DNA methyltransferases (DNMTs) play a vital role in DNA methylation in the …