Targeted therapies and the consequent adoption of “personalized” oncology have achieved
notable successes in some cancers; however, significant problems remain with this …

Among the epigenetic changes, histone acetylation has been recognized as a fundamental
process that strongly affects gene expression regulation. Disrupt of this phenomenon has …

Background & Aims Many genetic and environmental factors, including family history, dietary
fat, and inflammation, increase risk for colon cancer development. Peroxisome proliferator …

DNA methylation plays key roles in diverse biological processes such as X chromosome
inactivation, transposable element repression, genomic imprinting, and tissue-specific gene …

Sirtuins are a family of deacetylases that target histone and non‐histone proteins and
require NAD+ as an enzymatic cofactor for their enzymatic activity. This requirement confers …

The knowledge of GBM has been closely related to general medical knowledge of the CNS
since these malignancies were first described more than 200 years ago. Several great leaps …

Human pluripotent embryonic stem cells have two special features: self-renewal and
pluripotency. It is important to understand the properties of pluripotent stem cells and …

The mechanisms of systemic pulmonary inflammation and toxicity of fine particulate matter
(PM 2.5) exposure remains unclear. The current study investigated the inflammatory …

DNA methyltransferases (DNMTs) are important enzymes involved in epigenetic control of
gene expression and represent valuable targets in cancer chemotherapy. A number of …

Simple Summary The roles of “like-Smith”(LSM) proteins in breast cancer development and
their clinical relevance remain unclear. In this study, multiple analyses based on 3593 …