It is 20 years since the identification of PKD1, the major gene mutated in autosomal
dominant polycystic kidney disease (ADPKD), followed closely by the cloning of PKD2 …

Abstract Polycystin-2 (TRPP2, PKD2, PC2) is the product of the PKD2 gene, whose
mutations cause Autosomal Dominant Polycystic Kidney Disease (ADPKD). PC2 belongs to …

Autosomal dominant polycystic kidney disease (ADPKD) is characterized by large fluid-filled
cysts and progressive deterioration of renal function necessitating renal replacement …

Mutations in PKD1 cause the majority of cases of autosomal dominant polycystic kidney
disease (ADPKD). Because polycystin 1 modulates cell proliferation, cell differentiation, and …

Autosomal dominant polycystic kidney disease (ADPKD) results from mutations in either
PKD1 or PKD2 and accounts for 10% of all patients on renal replacement therapy. The …

Background. Autosomal dominant polycystic kidney disease (ADPKD) is the most common
inherited human kidney disease and is caused by germline mutations in PKD1 (85%) or …

Polycystic kidney diseases are the most common genetic diseases that affect the kidney.
There remains a paucity of information regarding mechanisms by which G proteins are …

Abstract Polycystin 2 (PC2 or TRPP1, formerly TRPP2) is a calcium-permeant Transient
Receptor Potential (TRP) cation channel expressed primarily on the endoplasmic reticulum …

Mutations in the polycystins cause autosomal dominant polycystic kidney disease (ADPKD).
Here we show that transmembrane protein 33 (TMEM33) interacts with the ion channel …

Although autosomal dominant polycystic kidney disease (ADPKD) is characterized by the
development of multiple kidney cysts, the most frequent cause of death in ADPKD patients is …