Inside cells, the endoplasmic reticulum (ER) forms the largest Ca 2+ store. Ca 2+ is actively
pumped by the SERCA pumps in the ER, where intraluminal Ca 2+-binding proteins enable …

Autosomal dominant polycystic kidney disease (ADPKD) affects an estimated 1 in 1,000
people and slowly progresses to end-stage renal disease (ESRD) in about half of these …

The association of overweight/obesity with disease progression in patients with autosomal
dominant polycystic kidney disease (ADPKD) remains untested. We hypothesized that …

Abstract Autosomal Dominant Polycystic Kidney Disease (ADPKD) is a slowly progressive
disease characterized by the relentless growth of renal cysts throughout the life of affected …

Mitochondria and the endoplasmic reticulum (ER) have an intimate functional relationship
due to tethering proteins that bring their membranes in close (~ 30 nm) apposition. One …

Background Data for the risk of any solid cancer in patients with polycystic kidney disease
are scarce. Therefore, we did a nationwide cohort study in Taiwan to establish the risk of …

Vasopressins are evolutionarily conserved peptide hormones. Mammalian vasopressin
functions systemically as an antidiuretic and regulator of blood and cardiac flow essential for …

Aquaporins (AQPs) are a family of highly selective transmembrane channels that mainly
transport water across the cell and some facilitate low-molecular-weight solutes. Eight AQPs …

Chronic kidney disease with uncertain etiology (CKDu) in Sri Lanka has attracted much
attention as a global health issue. However, how environmental factors in local drinking …

Abstract Autosomal Dominant Polycystic Kidney Disease (ADPKD) is a genetic disorder
caused by loss-of-function mutations in PKD1 or PKD2. Increased glycolysis is a prominent …