To maintain iron homeostasis, fungi have to balance iron acquisition, storage, and utilization
to ensure sufficient supply and to avoid toxic excess of this essential trace element. As …

The synthesis and trafficking of iron-sulfur (Fe-S) clusters in both prokaryotes and
eukaryotes requires coordination within an expanding network of proteins that function in the …

Plant pathogens are challenged by host-derived iron starvation or excess during infection,
but the mechanism through which pathogens counteract iron stress is unclear. Here, we …

The fungal pathogen Cryptococcus neoformans is well adapted to its host environment. It
has several defence mechanisms to evade oxidative and nitrosative agents released by …

Nutrient sensing is critical for adaptation of fungi to environmental and host conditions. The
conserved cAMP/PKA signaling pathway contributes to adaptation by sensing the …

Antimicrobial resistance is becoming one of the most important human health issues.
Accordingly, the research focused on finding new antibiotherapeutic strategies is again …

Iron homeostasis in fungi involves balancing iron uptake and storage with iron utilization to
achieve adequate, nontoxic levels of this essential nutrient. Extensive work in the …

Iron is an essential micronutrient for virtually all eukaryotic organisms and plays a central
role during microbial infections. Invasive fungal diseases are associated with strikingly high …

The oxidative stress response is required for plant pathogens to endure host-derived
oxidative stress during infection. Previously, we identified the eight transcription factors (TFs) …

Among the thioredoxin superfamily of proteins, the observation that numerous glutaredoxins
bind iron-sulphur (Fe/S) clusters is one of the more recent and major developments …