DNA methylation plays an important role in epigenetic signalling, having an impact on gene
regulation, chromatin structure, development and disease. Here, we review the structures …

Messenger RNA decay is an essential step in gene expression to set mRNA abundance in
the cytoplasm. The binding of proteins and/or noncoding RNAs to specific recognition …

Circular RNAs are a large group of noncoding RNAs that are widely expressed in
mammalian cells. Genome-wide analyses have revealed abundant and evolutionarily …

Evidence is emerging that several diseases and behavioral pathologies result from defects
in gene function. The best-studied example is cancer, but other diseases such as …

Messenger ribonucleic acid (mRNA) turnover is a major control point in gene expression. In
mammals, many mRNAs encoding inflammatory cytokines, oncoproteins, and G‐protein …

Chromatin modifications–including DNA methylation, modification of histones and
recruitment of noncoding RNAs–are essential epigenetic events. Multiple sequential …

Methylation of DNA at 5-position of cytosine, catalyzed by DNA methyltransferases, is the
predominant epigenetic modification in mammals. Aberrations in methylation play a causal …

A hallmark of cancer is aberrant DNA methylation, consisting of global hypomethylation and
regional hypermethylation of tumor suppressor genes. DNA methyltransferase inhibitors …

Hypermethylation-mediated tumor suppressor gene silencing plays a crucial role in
tumorigenesis. Understanding its underlying mechanism is essential for cancer treatment …

DNA methylation is one of the principal epigenetic signals that participate in cell specific
gene expression in vertebrates. DNA methylation plays a quintessential role in the control of …