As a preformed defense system, complement faces a delicate challenge in providing an
immediate, forceful response to pathogens even at first encounter, while sparing host cells in …

Age-related macular degeneration (AMD) is a progressive retinal disease and the major
cause of irreversible vision loss in the elderly. Numerous studies have found both common …

Thrombotic microangiopathy (TMA) is a condition characterized by thrombocytopenia and
microangiopathic hemolytic anemia (MAHA) with varying degrees of organ damage in the …

The relationship between the complement system and autoimmunity appears paradoxical as
both the deficiency and the activation contribute to inducing autoimmune diseases. In these …

Age-related macular degeneration (AMD) is the main cause of vision loss among the elderly
in the Western world. While AMD is a multifactorial disease, the complement system was …

The complement system, while being an essential and very efficient effector component of
innate immunity, may cause damage to the host and result in various inflammatory …

Atypical hemolytic uremic syndrome (aHUS) is a life-threatening thrombotic microangiopathy
that can progress, when untreated, to end-stage renal disease. Most frequently, aHUS is …

Two complex protein defense systems—complement and coagulation—are based on
amplifying enzyme cascades triggered by specific local stimuli. Excess systemic activation of …

Transplant-associated thrombotic microangiopathy (TA-TMA) is a life-threatening
complication of allogeneic hematopoietic cell transplantation (HCT). We hypothesized that …

Factor I (FI) is one of the main inhibitors of complement activity, and numerous rare coding
variants have been reported in patients with age-related macular degeneration, atypical …