Physical activity and sports play major roles in the overall health status of humans. It is well
known that regular exercise helps to lower the risk for a broad variety of health problems …

Epigenetics connects genetic and environmental factors: it includes DNA methylation,
histone post‐translational modifications and the regulation of chromatin accessibility by non …

Evidences highlight the role of various CD4+ helper T cells (CD4+ Th) subpopulations in
orchestrating the immune responses against cancers. Epigenetics takes an important part in …

Rationale: As the third leading cause of death in the United States, the impact of chronic
obstructive pulmonary disease (COPD) makes identification of its molecular mechanisms of …

Rationale: Although sunitinib has been shown to improve the survival rate of advanced renal
cell carcinoma (RCC) patients, poor drug response is a major challenge that reduces patient …

Accumulating animal and human data indicate that environmental exposures experienced
during sensitive developmental periods may strongly influence risk of adult disease …

Antipsychotic medications are essential when treating schizophrenia spectrum and other
psychotic disorders, but the efficacy and tolerability of these medications vary from person to …

The title usage of Latin Quo vadis 'where are you going'extends the question Unde venisti
from where 'did you come?'posed in the accompanying paper and extends consideration of …

Purpose Although surgical resection combined with neoadjuvant radiation therapy can
reduce the local recurrence rate of rectal cancer, not all patients benefit from neoadjuvant …

Background: Drug-induced liver injury (DILI) is a common and serious adverse drug reaction
with insufficient clinical diagnostic strategies and treatment methods. The only clinically well …