Melanoma is the most lethal skin cancer that originates from the malignant transformation of
melanocytes. Although melanoma has long been regarded as a cancerous malignancy with …

Epigenetic alternations concern heritable yet reversible changes in histone or DNA
modifications that regulate gene activity beyond the underlying sequence. Epigenetic …

The mechanisms underlying innate immune memory have been extensively explored in the
last decades but are in fact largely unknown. Although the specificity of adaptive immune …

DNA methylation is an important epigenetic mechanism that regulates gene expression. To
date, most DNA methylation studies have focussed on CpG islands in the gene promoter …

Anabolic-androgenic steroids (AASs) are a large group of molecules including
endogenously produced androgens, such as testosterone, as well as synthetically …

Methylation of cytosines in the mammalian genome represents a key epigenetic modification
and is dynamically regulated during development. Compelling evidence now suggests that …

How DNA methylation is interpreted and influences genome regulation remains largely
unknown. Proteins of the methyl-CpG-binding domain (MBD) family are primary candidates …

DNA methylation acts as an epigenetic modification in vertebrate DNA. Recently it has
become clear that the DNA and histone lysine methylation systems are highly interrelated …

Facioscapulohumeral dystrophy (FSHD) is associated with somatic chromatin relaxation of
the D4Z4 repeat array and derepression of the D4Z4-encoded DUX4 retrogene coding for a …

The promise of targeting epigenetic abnormalities for cancer therapy has not been realized
for solid tumours, although increasing evidence is demonstrating its worth in haematological …